The disease (COVID-19) novel coronavirus pandemic has so far infected millions resulting in the death of over a million people as of Oct 2020. More than 90% of those infected with COVID-19 show mild or no symptoms but the rest of the infected cases show severe symptoms resulting in significant mortality. Age has emerged as a major factor to predict the severity of the disease and mortality rates are significantly higher in elderly patients. Besides, patients with underlying conditions like Type 2 diabetes, cardiovascular diseases, hypertension, and cancer have an increased risk of severe disease and death due to COVID-19 infection. Obesity has emerged as a novel risk factor for hospitalization and death due to COVID-19. Several independent studies have observed that people with obesity are at a greater risk of severe disease and death due to COVID-19. Here we review the published data related to obesity and overweight to assess the possible risk and outcome in Covid-19 patients based on their body weight. Besides, we explore how the obese host provides a unique microenvironment for disease pathogenesis, resulting in increased severity of the disease and poor outcome.

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Ubiquitous fine particulates can readily be bound to toxic metals and polycyclic aromatic hydrocarbons and are considered to be a great threat to human health. The purpose of this study was to assess the magnitude of air pollution risks to public health by determining four crucial parameters- inhalable particulates, metals in particulates and PAHs which are associated with PM₁₀ in the air environment of Lucknow, India during 2007-09. The values of PM₁₀ and PM₂.₅ ranged between 102.3-240.5 and 28.0-196.9 μg/m³ whilst the average PM₁₀ was 1.7 times and PM was 1.5 times higher than their respective NAAQS of 100 and 60 μg/m³ respectively. The estimated relative death rate and hospital admissions for each increase in the PM₁₀ levels of 10 μg/m³ ranged from 1.5-8% and from 3.9-8.0% (as per APHEA2 1990) respectively in persons > 65 yrs. Among the locations; AQ, AQ and AQ (with diversified activities and heavy traffic) recorded higher concentrations of both the particulate fractions than the AQ (residential area with low traffic). The average concentrations of Fe, Pb, Ni, Cu, Cr, Cd in PM₁₀ were 219.4, 40.6, 35.1, 27.3, 22.2 and 16.2 ng/m³ and that in PM₂.₅ were 54.3, 33.9, 38.5, 29.4, 8.4, and 1.17 ng/m³ respectively Regression analysis revealed that correlation of metals with PM₂.₅ was stronger than PM. The ratio of metals adsorbed on surface of particles (PM₂.₅:PM₁₀) reveals that PM₂.₅ has more affinity for Ni, Cu and Pb and PM₁₀ for Cd, Fe and Cr. Health risk due to carcinogenic metals bound to respirable particulates was predicted by estimating excess cancer risk (ECR). The highest ECR value was estimated for Cr, 266.70 × 10⁻⁶, which was associated with PM10 and 100.92 × 10⁻⁶ which was associated with PM₂.₅, whereas lead has the lowest ECR value. Amongst PAHs, benzo(a)pyrene (51.96 ± 19.71 ng/m) was maximum in PM₁₀ samples. Maximum concentrations of PM₁₀, PM₂.₅, metals and PAHs were detected during winter, and the lowest was during monsoon. The higher prevalence of diseases among the population may be due to high concentration of particulates coated with toxic metals and PAHs present in air environment.

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The PM(10) concentration (μg/m(3)) in Lucknow city at 4 locations in three different seasons ranged between 148.6-210.8 (avg. 187.2 ± 17.1) during summer, 111.8-187.6 (avg. 155.7 ± 22.7) during monsoon and 199.3-308.8 (avg. 269.3 ± 42.9) during winter while PM(2.5) ranged between 32.4-67.2 (avg. 45.6 ± 10.9), 25.6-68.9 (avg. 39.8 ± 4.6) and 99.3-299.3 (avg. 212.4 ± 55.0) during respective seasons. The mass fraction ratio of PM(2.5) ranged between 0.22-0.92 (avg. 0.42 ± 0.26) and was significantly high during winter season indicating their composition.

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