Colorectal cancer (CRC) is a universal heterogeneous disease that is characterized by genetic and epigenetic alterations. Immunotherapy using monoclonal antibodies (mAb) and cancer vaccines are substitute strategies for CRC treatment. When cancer immunotherapy is combined with chemotherapy, surgery, and radiotherapy, the CRC treatment would become excessively efficient. One of the compelling immunotherapy approaches to increase the efficiency of CRC therapy is the deployment of therapeutic mAbs, nanobodies, bi-specific antibodies and cancer vaccines, which improve clinical outcomes in patients. Also, among the possible therapeutic approaches for CRC patients, gene vaccines in combination with antibodies are recently introduced as a new perspective. Here, we aimed to present the current progress in CRC immunotherapy, especially using Bi-specific antibodies and dendritic cells mRNA vaccines. For this aim, all data were extracted from Google Scholar, PubMed, Scopus, and Elsevier, using keywords cancer vaccines; CRC immunotherapy and CRC mRNA vaccines. About 97 articles were selected and investigated completely based on the latest developments and novelties on bi-specific antibodies, mRNA vaccines, nanobodies, and MGD007.

The results of this in vitro study demonstrated that NS can be used as a worthy preserver for harvested vessels for up to 21 days, especially in resource-limited transplantation centers.

Perforation of Meckel’s diverticulum is a rare complication in neonatal period. A 3-dayold term male neonate was transferred to our emergency room due to bowel perforation. Surgical exploration was done and perforated Meckel’s diverticulum was detected. Pathological report of the tissue showed inflamed diverticulum with heterotopic gastric mucosa. This is the first report of Meckel’s diverticulum perforation in a neonate in our country

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Background: Idiopathic granulomatous mastitis (IGM) is a rare non-specific inflammatory breast disease and is usually considered a kind of autoimmune disease. There are several controversies regarding its standard treatment. We aimed to evaluate the efficacy of local corticosteroid injection for the treatment of breast-limited idiopathic granulomatous mastitis.Methods: This randomized prospective clinical trial study evaluated the clinical response rate of local steroid injection to treat breast-limited IGM in women. The subjects received local steroid injection of long-action (LA) Betamethasone combined with standard systemic treatments (prednisolone, Methotrexate) (Combine therapy group), standard systemic treatments alone (Systemic group), or local steroid injection alone (LA Betamethasone, Injection group). Clinical benefits and recurrence rates were compared in the three groups.Results: All of the patients were women, and their mean age was 34 years. The excellent clinical or radiological response was observed in 20/31 (64.5%), 24/38 (63.1%), and 17/30 (56.6 %) patients in the injection, combined, and systemic therapy groups, respectively. During the follow-up of 10 months in patients who received local steroid injection alone, recurrence was observed in six patients (16.4%, 6/31), and no side effects or injection steroid-related complications occurred. The local recurrence rate in systemic and combined therapy groups were 3.3 % (1/30) and 13.2 % (5/38) patients, respectively.Conclusions: Our findings suggest that local betamethasone LA injection in breast limited IGM is as successful as current standard treatment and shortens the complete healing time compared to treatment with systemic therapy. Short time recurrence rate was not statistically significant among the groups. Local injection could be a beneficial option in the treatment of IGM. Trial registration: The trial registry number was IRCT20200608047694N1. Registration date: 2020-07-21.

Background: Suturing quality and reducing its complications and resulting infection have always been a major concern of surgeons. Many of them have prohibited applying polyfilament and absorbable suturing materials. Objectives: In this study, we compared skin wound infection rate and other complications in two groups of post appendectomy patients whom were treated with two types of suturing materials -conventionally used Nylon and absorbable braided polyglactin (Vicryl) -and wound healing, existence of complication and recovery course of treated patients were surveyed. Patients and Methods: A total of 130 patients who underwent appendectomy were divided into two groups of 645 members, each. Patients in group A had their incisions closed by separate sutures (mattress method) by vicryl, while patients in group B had their surgical incisions were closed in the same method, by nylon sutures. Any signs and symptoms of surgical site wound infection like inappropriate pain, redness, discharge, bulging, and unhealing wound were checked during hospital stay and on the 7 th -9 th day postoperatively. Results: The postsurgical complication and infections rates were similar between the two groups. Conclusions: Vicryl sutures can safely be used for skin and subcutaneous wound suturing even when our surgery site is not ideally clean.