Comparison of Infection Incidence Between Appendectomy Skin Incisions Sutured by Nylon and Polyglactin (Vicryl)

Golchini, Alireza; Jamnani, Habib Alah Nikzad; Ahmadi, Shamseddin; Karimi, Elham; Pourahmad, Saeedeh; Safarpour, Ali Reza; Zabangirfard, Zahra; Ghahramani, Leila

doi:10.17795/colorectalresearch30179

Cited by 1 publication

(2 citation statements)

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“…The incidence of surgical site/wound infection was the most common outcome measured of the included studies. [23][24][25][26][27][28][29][30][31][32][33][34][35] Infection rates were reported in all ten General Surgery studies, two studies from Orthopaedic surgery, three from Dermatology, and one each from Internal Medicine and Plastic Surgery. Bloemen et al 36 conducted a randomized clinical trial to investigate the incidence of SSI, incisional hernia and suture sinus using Prolene Õ (polypropylene) or PDS Õ (polydioxanone) to close the fascia after abdominal surgery.…”

Section: Search Resultsmentioning

confidence: 99%

“…The incidence of surgical site/wound infection was the most common outcome measured of the included studies. 23–35 Infection rates were reported in all ten General Surgery studies, two studies from Orthopaedic surgery, three from Dermatology, and one each from Internal Medicine and Plastic Surgery. Bloemen et al.…”

Section: Systematic Review Of the Clinical Literaturementioning

confidence: 99%

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Synthetic sutures: Clinical evaluation and future developments

et al. 2017

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Today's sutures are the result of a 4000-year innovation process with regard to their materials and manufacturing techniques, yet little has been done to enhance the therapeutic value of the suture itself. In this review, we explore the historical development, regulatory database and clinical literature of sutures to gain a fuller picture of suture advances to date. First, we examine historical shifts in suture manufacturing companies and review suture regulatory databases to understand the forces driving suture development. Second, we gather the existing clinical evidence of suture efficacy from reviewing the clinical literature and the Food and Drug Administration database in order to identify to what extent sutures have been clinically evaluated and the key clinical areas that would benefit from improved suture materials. Finally, we apply tissue engineering and regenerative medicine design hypotheses to suture materials to identify routes by which bioactive sutures can be designed and passed through regulatory hurdles, to improve surgical outcomes. Our review of the clinical literature revealed that many of the sutures currently in use have been available for decades, yet have never been clinically evaluated. Since suture design and development is industry driven, incremental modifications have allowed for a steady outflow of products while maintaining a safe regulatory position and limiting costs. Until recently, there has been little academic interest in suture development, however the rise of regenerative medicine strategies is shifting the suture paradigm from an inert material, which mechanically approximates tissue, to a bioactive material, which also actively promotes cell-directed repair and a positive healing response. These materials hold significant therapeutic potential, but could be associated with an increased regulatory burden, cost, and clinical evaluation compared with current devices.

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