Higher house dust levels of PBDE flame retardants (FRs) have been
reported in California than other parts of the world, due to the state’s
furniture flammability standard. However, changing levels of these
and other FRs have not been evaluated following the 2004 U.S. phase-out
of PentaBDE and OctaBDE. We analyzed dust collected in 16 California
homes in 2006 and again in 2011 for 62 FRs and organohalogens, which
represents the broadest investigation of FRs in homes. Fifty-five
compounds were detected in at least one sample; 41 in at least 50%
of samples. Concentrations of chlorinated OPFRs, including two (TCEP
and TDCIPP) listed as carcinogens under California’s Proposition
65, were found up to 0.01% in dust, higher than previously reported
in the U.S. In 75% of the homes, we detected TDBPP, or brominated
“Tris,” which was banned in children’s sleepwear
because of carcinogenicity. To our knowledge, this is the first report
on TDBPP in house dust. Concentrations of Firemaster 550 components
(EH-TBB, BEH-TEBP, and TPHP) were higher in 2011 than 2006, consistent
with its use as a PentaBDE replacement. Results highlight the evolving
nature of FR exposures and suggest that manufacturers continue to
use hazardous chemicals and replace chemicals of concern with chemicals
with uncharacterized toxicity.
Human exposure to mixtures of polychlorinated biphenyls (PCBs) may result in the formation of different profiles of hydroxylated PCBs (HO-PCBs), as a consequence of different exposures or dissimilar metabolism of parent compounds. Therefore, we investigated the levels and profiles of PCBs and HO-PCBs in human serum samples collected from two European countries with different degrees of pollution. There was no significant difference between the levels of sum PCBs measured in each set of samples, with a median concentration of 3100 pg/mL for Romanian samples (n = 53) and 3380 pg/mL for Belgian samples (n = 22). However, the median concentrations recorded for sum HO-PCBs were almost double in Belgian (310 pg/mL) compared to Romanian (175 pg/mL) samples. The detection frequency recorded for HO-PCBs in Belgian samples was also significantly higher compared to Romanian samples. The main contributors to the sum HO-PCBs in the Belgian samples were 4HO-CB107 > 4HO-CB146 > 4HO-CB187 (76% from the sum HO-PCBs) and 4HO-CB187 > 4HO-CB146 > 3'HO-CB138 (66% from the sum of HO-PCBs) in the Romanian samples. The HO-PCB profile showed that the higher chlorinated HO-PCBs had a higher contribution in the Romanian samples compared to the Belgian ones. This suggests that differences in the PCB profiles between populations can lead to the formation of different HO-PCB metabolite profiles presenting thus different risks for populations. No clear preferential mechanism of HO-PCB metabolite formation (HO-direct insertion vs. 1,2-shift of a chlorine atom) could be highlighted for investigated samples. The main chlorinated phenolic compound found in the Belgian samples was pentachlorophenol (PCP) which accounted for up to 85% of the total quantified phenolics, whereas in the Romanian samples, PCP accounted for only 35%.
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