Geometric data are fundamental to the design of a contactor. The efficiency of a membrane contactor is mainly defined by its mass-transfer coefficient. However, design modifications also have significant effects on the performance of membrane contactors. In a hollow-fiber membrane oxygenator (HFMO), properties such as priming volume and effective membrane surface area (referred to as design specifications) can be determined. In this study, an extensive theoretical model for calculation of geometric data and configuration properties, and, consequently, optimization of the design of an HFMO, is presented. Calculations were performed for Oxyphan(®) hollow-fiber micro-porous membranes, which are frequently used in current HFMOs because of their high gas exchange performance. The results reveal how to regulate both the transverse and longitudinal pitches of fiber bundles to obtain a lower rand width and a greater number of windings. Such modifications assist optimization of module design and, consequently, substantially increase the efficiency of an HFMO. On the basis of these considerations, three values, called efficiency factors, are proposed for evaluation of the design specifications of an HFMO with regard with its performance characteristics (i.e. oxygen-transfer rate and blood pressure drop). Moreover, the performance characteristics of six different commercial HFMOs were measured experimentally, in vitro, under the same standard conditions. Comparison of calculated efficiency factors reveals Quadrox(®) is the oxygenator with the most efficient design with regard with its performance among the oxygenators tested.

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The semiempirical hemolysis model introduced in this paper aims for significantly enhanced conformity with experimental data. Two phenomenological outcomes become possible with the proposed approach: an estimation of the average time after which cell membrane breakdown occurs under the applied conditions, and a prediction of the ratio between the phenomena involved in hemolysis.

Objectives: Contemporary therapies for chronic kidney disease patients encompass a wide range of hemodialysis treatments, most of which rely greatly on dialyzers and hemofilters. The filtration process taking place in these devices with respect to the hemodynamic characteristics of the flow, has not yet been fully investigated. This study aims at improving the understanding of hemodynamics in a dialyzer by employing experimental methods and mathematical models. Methods: A semiempirical model has been formulated based on the principles of hemodynamics, considering the dominant phenomena of filtration-backfiltration and the corresponding driving forces. An in vitro hemodialysis circuit was accordingly assembled for experimental data acquisition, and subsequently for model validation. The circuit consisted of two dialyzers arranged in sequential order, in pursuance of increasing the number of sampling points. Fresh, heparinized porcine blood was used throughout the course of this study. Pressure and flow data obtained from in vitro investigations with the hemodialysis circuit were used as an input for the semiempirical model. Findings: The model predicted a substantial divergence in the course of hematocrit value along the length of the hollow fibers, which is corroborated by the experimental data. Particularly in certain operational conditions, hematocrit rose from 25% at the inlet to 65% halfway along the dialyzers’ length, to end at 30% at the outlet. Conclusion: Validation of the model’s predictions with experimental data demonstrated a very good agreement, confirming the model’s accuracy. Potential implementation of the model in clinical practice in the future might contribute greatly to an improved hemodialysis experience.