A New Approach for Semiempirical Modeling of Mechanical Blood Trauma

Poorkhalil, Ali; Amoabediny, Ghassem; Tabesh, Hadi; Behbahani, Mehdi; Mottaghy, K.

doi:10.5301/ijao.5000474

Cited by 7 publications

(4 citation statements)

References 20 publications

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“…Hemolysis, or damage to erythrocytes, has already been extensively investigated and is still one of the most important parameters to evaluate devices in terms of blood damage. Whereas the effects leading to lethal damage of erythrocytes are well investigated (9), Olia et al (10) and Poorkhalil et al (11) highlight a less known topic: the sublethal damage of erythrocytes. Olia et al summarize the current understanding of this topic in a review (10).…”

Section: Summary Of Contentsmentioning

confidence: 99%

“…Olia et al summarize the current understanding of this topic in a review (10). Poorkhalil et al suggest a numerical model that considers not only the breakdown of the erythrocyte cell membrane but also the release of hemoglobin through the functional membrane (11). Another parameter that has important effects on blood damage is the roughness of the surface in contact with blood.…”

Section: Summary Of Contentsmentioning

confidence: 99%

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Blood Damage in Ventricular Assist Devices

2016

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leading to adverse events and focus on the development of less traumatic pumps. It is commonly agreed that a major part of the complications are related to device-induced effects on blood. On their way through the pump and its cannulae, blood components are subjected to strong influences that may either damage cells or proteins or enhance thrombogenesis. Although intensive research has been focused on blood damage, the underlying mechanisms are still not well understood in their entire complexity. This special issue thus addresses important aspects of blood damage in VADs. Most contributions evolved from presentations given at the European Society of Artificial Organs congress held in Rome in 2014, where the idea for the scope of this special issue emerged. Other experts were also recruited, making this issue an important contribution to current research in this field. This editorial summarizes these contributions and highlights the future challenges that should be addressed.

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Section: Summary Of Contentsmentioning

confidence: 99%

Section: Summary Of Contentsmentioning

confidence: 99%

Blood Damage in Ventricular Assist Devices

2016

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“…How such sublytic damage correlates with the scalar stress versus the full stress tensor is an important, related question. In addition, a recent model [176] supports the idea that membrane failure comprises diffusive transport through temporary pores in an otherwise intact membrane at low stress [144] and largescale rupture at high stress (as assumed by many early models), which adds another layer of complexity to this challenging problem.…”

Section: Discussionmentioning

confidence: 80%

“…The resulting mass transport coefficient was in the same range as that of Vitale, et al[144], but is less empirical.For higher stresses, unstable growth of pores may lead to catastrophic membrane rupture. Poorkhalil, et al[176] developed a semi-empirical hemolysis model adding this phenomenon. Their model included Fickian diffusion of Hb through pores at lower levels of shear stress and a second term accounting for release of all intracellular hemoglobin beyond a threshold shear stress.…”

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confidence: 99%

Improving flow-induced hemolysis prediction models.

Faghih¹

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Sharp, who has been a helpful teacher, a kind mentor and a great friend throughout my study. Without his unfailing patience and never-ending motivation and guidance, none of this work would have been possible. He has extensively contributed to my personal as well as professional growth. I would also like to thank Dr. George Pantalos, Dr. Stuart Williams and Dr. Srinivasan C. Rasipuram, for accepting to be on my dissertation committee and for providing their constructive advice during my research at the University of Louisville. Particularly, I would want to thank Dr. George Pantalos for providing me with the human blood samples for the experimental part of my research. Additionally, I want to thank Dr. Stuart Williams for providing me with some of the lab facilities I needed for my experiment, including but not limited to the 40X Extra Long Working Distance microscope objective. Furthermore, I must show my appreciation for various faculty and staff at the University of Louisville, especially John Jones, the technician at the Mechanical Engineering Department. John Jones has, indeed, helped me a lot with design, machining, fabrication and assemblage of different devices throughout my research.

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Characterization of erythrocyte membrane tension for hemolysis prediction in complex flows

Faghih

Sharp

2018

Biomech Model Mechanobiol

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Hemolysis is a persistent issue with blood-contacting devices. Many experimental and theoretical contributions over the last few decades have increased insight into the mechanisms of hemolysis in both laminar and turbulent flows, with the ultimate goal of developing a comprehensive, mechanistic hemolysis model. Many models assume that hemolysis scales with a resultant, scalar stress representing all components of the fluid stress tensor. This study critically evaluates this scalar stress hypothesis by calculating the response of the red blood cell membrane to different types of fluid stress (laminar shear and extension, and three turbulent shear and extension cases), each with the same scalar stress. It was found that even though the scalar stress is the same for all cases, membrane tension varied by up to three orders of magnitude. In addition, extensional flow causes constant tension, while tank-treading in shear flow causes periodic tension, with tank-treading frequency varying by three orders of magnitude among the cases. For turbulent flow, tension also depends on eddy size. It is concluded, therefore, that scalar stress alone is inadequate for scaling hemolysis. Fundamental investigations are needed to establish a new index of the fluid stress tensor that provides reliable hemolysis prediction across the wide range of complex flows that occur in cardiovascular devices.

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A New Approach for Semiempirical Modeling of Mechanical Blood Trauma

Cited by 7 publications

References 20 publications

Blood Damage in Ventricular Assist Devices

Blood Damage in Ventricular Assist Devices

Improving flow-induced hemolysis prediction models.

Characterization of erythrocyte membrane tension for hemolysis prediction in complex flows

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