Injectable conductive nanocomposite hydrogels for cardiac tissue engineering: Focusing on carbon and metal-based nanostructures

Pournemati, Behnam; Tabesh, Hadi; Jenabi, Alireza; Aghdam, Rouhollah Mehdinavaz; Rezayan, Ali Hossein; Poorkhalil, Ali; Tafti, Seyed Hossein Ahmadi; Mottaghy, K.

doi:10.1016/j.eurpolymj.2022.111336

Cited by 13 publications

(4 citation statements)

References 189 publications

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“…The application of hydrogels in the repair and regeneration of damaged hearts was discussed [ 6 , 7 , 8 ].…”

Section: Resultsmentioning

confidence: 99%

“…Injectable conductive carbon and metal-based nanocomposite hydrogels for cardiac tissue engineering were reviewed [ 8 ]. It would be beneficial in the near future to study the role and impact of nanoparticle rigidity quantitatively and in more detail, especially in the context of mechanical moduli improvement and in cardiac tissue engineering.…”

Section: Resultsmentioning

confidence: 99%

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Nanocomposite Hydrogels and Extracellular Matrix—Advantages and Associated Risks

Kerch

2023

Gels

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Hydrogels can be considered as mimics of the extracellular matrix (ECM). Through integrins, the cytoskeleton is connected to the ECM, and cytoskeleton tension depends on ECM stiffness. A number of age-related diseases depend on cellular processes related to cytoskeleton function. Some examples of cancer initiation and progression and heart disease in relation to ECM stiffness have been analyzed. The incorporation of rigid particles into the ECM can increase ECM stiffness and promote the formation of internal residual stresses. Water migration, changes in water binding energy to biomactomolecules, and changes in the state of water from tightly bound water to free and loosely bound water lead to changes in the stiffness of the ECM. Cardiac tissue engineering, ECM stiffness and cancer, the equivalence of ECM stiffness, oxidative stress, inflammation, multi-layer polyelectrolyte complex hydrogels and bioprinting, residual internal stresses, viscoelastic hydrogels, hydrogel nanocomposites, and the effect of water have been reported. Special attention has been paid to the role of bound water and internal stresses in ECM stiffness. The risks related to rigid particle incorporation into the ECM have been discussed. The potential effect of polyphenols, chitosan, and chitosan oligosaccharide on ECM stiffness and the potential for anti-TNF-α and anti-NF-κB therapies have been discussed.

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“…The application of hydrogels in the repair and regeneration of damaged hearts was discussed [ 6 , 7 , 8 ].…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Nanocomposite Hydrogels and Extracellular Matrix—Advantages and Associated Risks

Kerch

2023

Gels

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“…31 Carbon nanotubes are hollow cylinders made from graphite sheets, with a diameter on the nanoscale and a length on the nano-or micron scale. 32 Due to the special structure, conductive hydrogels achieved using CNTs as conductive fillers have better mechanical properties, exhibiting obvious advantages in the application of wearable sensors. 33 However, the direct addition of carbon nanotubes would easily induce aggregation for hydrogels containing a large amount of water, affecting the mechanical uniformity and electrical conductivity.…”

Section: Classification Of the Conductive Hydrogelsmentioning

confidence: 99%

Recent progress in the development of conductive hydrogels and the application in 3D printed wearable sensors

Lin,

Yang,

2023

RSC Appl. Polym.

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“…Hydrogels have a wide range of therapeutic uses, such as in engineering, as drug transporters, and in wound healing, because of their three-dimensional structure and softness. , However, the weak mechanical qualities of hydrogels have long been a source of concern. − Therefore, natural materials are frequently used to minimize toxicity and increase their mechanical qualities. , …”

Section: Introductionmentioning

confidence: 99%

Flexible Wood-Based Janus Hydrogel for Nasal Infection

He,

Liu,

Zhu

et al. 2024

ACS Sustainable Chem. Eng.

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Nasal diseases are pervasive infections that can impair the quality of life of sufferers. In this study, a flexible modified triplochitin scleroxylon (MTS)-based Janus hydrogel (MTS@P/DLT) was obtained by disrupting the homogeneity of the system using DL-α-tocopherol (DLT) with flexible wood as the framework and poly(vinyl alcohol) (PVA) as the outer matrix. At a PVA concentration of 10 wt %, DLT formed a homogeneous layer, as revealed by electron microscopy. Mechanical property analysis showed that chemical and hydrogel modifications significantly increased the flexibility and toughness of the hydrogel. Microscopic and macroscopic assessment of the characteristics of the two sides of the MTS@P/DLT hydrogel revealed that one side of the DLT film had antiadhesion effects. Molecular dynamics simulation was used to determine the movement law of DLT in a PVA solution. The stronger intermolecular force between DLT and PVA than that between DLT and water, as well as between DLT molecules, enabled the formation of a homogeneous DLT film by controlling the concentration of PVA. In vitro and in vivo models demonstrated the potential of MTS@P/DLT to resist infection and facilitate recovery. Thus, MTS@P/DLT is promising for medical use.

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Injectable conductive nanocomposite hydrogels for cardiac tissue engineering: Focusing on carbon and metal-based nanostructures

Cited by 13 publications

References 189 publications

Nanocomposite Hydrogels and Extracellular Matrix—Advantages and Associated Risks

Nanocomposite Hydrogels and Extracellular Matrix—Advantages and Associated Risks

Recent progress in the development of conductive hydrogels and the application in 3D printed wearable sensors

Flexible Wood-Based Janus Hydrogel for Nasal Infection

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