The present study was undertaken to evaluate of Nigella sativa oil (NSO) and zinc-silver cream in a rat model of wound healing by means of clinical appearance, histopathology, oxidative stress parameters, and biomechanical tests. The rats were divided into three groups, each having twenty animals. Group 1 served as a control having wound. Other two groups received either NS oil or zinc-silver cream in addition to the wound. The study was initiated after the animals rested for 2 weeks for acclimation. Blood samples were collected from 10 randomly selected animals from each group at days 0, 3, 7 and 14 for oxidative stress measurements. Differences among groups for blood lipid peroxidation and antioxidant values were determined with respect to biochemical oxidative stress results (P<0.01). Wound sites of 10 animals from each group were allocated for histopathological examinations, and those of the remaining 10 animals from each group were used in biomechanical testing. Histopathological examination revealed that epithelization occurred in all groups. Inflammatory response with an intensive vascularization was present in the samples of the silver group (P<0.01). Consequently, zinc-silver group has differed positively in terms of biochemical and biomechanical and histological aspects compared to other groups for wound healing and oxidative stress.
The aim of the study was to evaluate the cardiorespiratory and clinical effects of propofol and remifentanil anesthesia compared to propofol and fentanyl anesthesia during ovariohysterectomy in dogs. Sixteen healthy dogs were randomly assigned to two groups. After premedication with atropine, anesthesia was induced with propofol and maintained with the infusion of propofol at a dose of 0.5 mg/kg/min. Once stable anesthesia was achieved, 1 µg/kg remifentanil or 2 µg/kg fentanyl was administered intravenously, and infusion was begun at a dose of 0.6 µg/kg/min and 0.5 µg/kg/min, respectively. Cardiorespiratory variables were recorded after propofol administration combined with remifentanil or fentanyl at 10-min intervals, and the quality of anesthesia, return of spontaneous ventilation, head lift and sternal position were also recorded. Apnea was observed after remifentanil and fentanyl administration in all dogs. Heart rate, systolic and mean arterial blood pressures tended to decrease rapidly after remifentanil and fentanyl administration, and during the first 20 min, in both groups. Although the difference between times was significant, the difference between groups was statistically insignificant. Recovery periods were longer in the fentanyl group than in the remifentanil group. The administration of propofol with remifentanil or fentanyl provides a stable haemodynamic state and depth of anesthesia with a constant infusion, and remifentanil could be preferred to fentanyl when aiming a rapid recovery period. Propofol, Remifentanil, Fentanyl, Anesthesia, Cardiorespiratory, Recovery, Dog Köpeklerde Ovariohisterektomi Operasyonunda Propofol-Remifentanil ve Propofol-Fentanil Anestezisinin Karşılaştırılması Keywords: ÖzetBu çalışmanın amacı köpeklerde ovariohysterektomi operasyonunda propofol-remifentanil ile propofol-fentanil anestezisinin etkinliğini ve kardiyorespiratorik etkilerini karşılaştırmaktır. Bu amaçla 16 adet yetişkin, dişi köpek rastgele iki gruba (n=8) ayrıldı. Anesteziye atropin ile premedikasyon yapılarak başlandıktan sonra propofol ile indüksiyon yapıldı ve 0.5 mg/kg/dk dozunda propofol infüzyonuna başlandı. Stabil anesteziden sonra ilk gruba 1 µg/kg remifentanil, ikinci gruba 2 µg/kg fentanyl bolus olarak uygulandı. Remifentanil ve fentanil infüzyonu sırasıyla 0.6 µg/kg/dk ve 0.5 µg/kg/dk dozunda devam edildi. Kardiyovasküler değişiklikler propofol sonrası, remifentanil veya fentanil sonrası ve operasyon süresince 10 dakika aralıklarla kaydedildi. Anestezinin derinliği, spontan ventilasyonun başlama, kafayı kaldırma ve sternal pozisyona gelme zamanları kaydedildi. Tüm olgularda remifentanil ve fentanil uygulamasından sonra apnea oluşumu gözlendi. Her iki grupta da kalp atım hızı, sistolik (SAP) ve ortalama arteriyel basınç (MAP) değerlerinin remifentanil ve fentanil uygulanmasından sonra hızla düştüğü ve ilk 20 dakikada düşmeye devam ettiği görüldü. Bu değerlerde zaman içindeki farklılıklar istatistiksel olarak anlamlı olarak kaydedilirken, gruplar arasında istatistiksel açıdan anlamlı olmadığı ...
Objective: Algan hemostatic agent (AHA) is a plant-based hemostatic agent produced in Turkey. Although, there is a great improvement in the hemostatic technologies, more effective hemostatic products are required to be produced. The aim of this study was to demonstrate the efficacy of AHA in a partial splenectomy model in rats. In addition, in this model, postoperative abdominal adhesion was evaluated. Materials and Methods: In this study 5-7 weeks old 64 rats were used. Rats were randomly divided into 8 groups, each consisting of eight rats (4 groups heparinized and 4 groups nonheparinized). Experimental splenectomy was performed and the gauze impregnated with saline was applied to the control group for the hemorrhage control, the gauze impregnated with liquid AHA, gel and powder form of AHA, was applied to the experimental groups. Results: The time to reach complete homeostasis was significantly shorter in all AHA groups compared to the control group. The powder and the gel forms of AHA stopped the bleeding in heparinized and non-heparinized groups in 1 second. The AHA fluid (sponge) form stopped the bleeding in the first application in the control group less than 10 seconds and the second time application was not necessary. The bleeding was able to be controlled in the heparinized control group (saline impregnated sponge) by 55 seconds and in the non-heparinized control group by 38 seconds. Conclusion: This study showed that AHA is a highly effective hemostatic agent, which would be beneficial in controlling hemorrhage.
IntroductionIsoflurane and sevoflurane are noncombustible halogenated anesthetic agents. In addition to a faster anesthesia induction and shorter recovery time, isoflurane also provides good muscle relaxation. Sevoflurane is more preferable than isoflurane because it has lower irritation of the respiratory tract than isoflurane and it has some advantages such as easy induction and a fast recovery compared to isoflurane (1-3).Propofol, a nonbarbiturate derivative, is a sedative and hypnotic drug that can be used in small animals for anesthesia and maintenance of sedation. Due to its shorter half-life and absence of accumulation in the body (4-6), it can be used safely in animals such as small ruminants (4,7). Information of the possible side effects of these types of anesthetics on small ruminants, however, is not present yet (8)(9)(10)(11)(12).Goats are preferred as an animal model in experimental studies such as orthopedic, cardiovascular, respiratory, and cerebrovascular studies (13-15). Sevoflurane, isoflurane, and halothane are often used as anesthetic agents. However, anesthetic requirements have not been determined in the goat for these agents accurately. Therefore, the aim of this research was to compare the anesthetic effects of two different inhalation anesthetics that are used in the maintenance of anesthesia with propofol medication. Materials and methodsThe study was approved by the Animal Research Local Ethics Committee of Kırıkkale University (Decision No: 70/09). Seven healthy adult female Angora goats were used in this study. Prestudy screening included a physical examination and complete blood count to ensure animals were in good health. The same goats were used for both anesthesia groups within a 2-week interval. Once anesthesia was induced with propofol, it was maintained either with isoflurane or sevoflurane.Feed and water were withheld from animals 18 h and 2 h prior to anesthesia respectively in order to prevent ruminal tympani during anesthesia. The medial auricular artery was catheterized (Wellcath-x plus 22G, Vellmed, Turkey) to measured systolic arterial pressure (SAP), diastolic arterial pressure (DAP), and mean arterial pressure (MAP). The caudal auricular vein was Abstract: Seven healthy Angora goats were used to compare the effects of isoflurane and sevoflurane on the cardiovascular and respiratory systems during anesthesia periods. Once anesthesia was induced with propofol at 5.1 ± 0.9 mg/kg, it was maintained with isoflurane at 1%-3% in the first treatment period and sevoflurane at 2%-4% in the second treatment period after a 15-day interval. Heart rates measured immediately after anesthesia induction and 5 min later were found to be statistically significant between anesthetic groups (P < 0.05). Mean blood pressure in the isoflurane group decreased (75.7 ± 7.2 to 59.8 ± 9.8 mmHg) (P < 0.05) throughout the anesthesia period. It was determined that respiratory rate in sevoflurane treatment was lower than that in isoflurane treatment. In terms of time to stand up, sevoflurane-adminis...
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