Comparison of sevoflurane and isoflurane effects on cardiovascular andrespiratory system during spontaneous ventilation in Angora goats

Abstract

IntroductionIsoflurane and sevoflurane are noncombustible halogenated anesthetic agents. In addition to a faster anesthesia induction and shorter recovery time, isoflurane also provides good muscle relaxation. Sevoflurane is more preferable than isoflurane because it has lower irritation of the respiratory tract than isoflurane and it has some advantages such as easy induction and a fast recovery compared to isoflurane (1-3).Propofol, a nonbarbiturate derivative, is a sedative and hypnotic drug that can be used in small animals for anesthesia and maintenance of sedation. Due to its shorter half-life and absence of accumulation in the body (4-6), it can be used safely in animals such as small ruminants (4,7). Information of the possible side effects of these types of anesthetics on small ruminants, however, is not present yet (8)(9)(10)(11)(12).Goats are preferred as an animal model in experimental studies such as orthopedic, cardiovascular, respiratory, and cerebrovascular studies (13-15). Sevoflurane, isoflurane, and halothane are often used as anesthetic agents. However, anesthetic requirements have not been determined in the goat for these agents accurately. Therefore, the aim of this research was to compare the anesthetic effects of two different inhalation anesthetics that are used in the maintenance of anesthesia with propofol medication. Materials and methodsThe study was approved by the Animal Research Local Ethics Committee of Kırıkkale University (Decision No: 70/09). Seven healthy adult female Angora goats were used in this study. Prestudy screening included a physical examination and complete blood count to ensure animals were in good health. The same goats were used for both anesthesia groups within a 2-week interval. Once anesthesia was induced with propofol, it was maintained either with isoflurane or sevoflurane.Feed and water were withheld from animals 18 h and 2 h prior to anesthesia respectively in order to prevent ruminal tympani during anesthesia. The medial auricular artery was catheterized (Wellcath-x plus 22G, Vellmed, Turkey) to measured systolic arterial pressure (SAP), diastolic arterial pressure (DAP), and mean arterial pressure (MAP). The caudal auricular vein was Abstract: Seven healthy Angora goats were used to compare the effects of isoflurane and sevoflurane on the cardiovascular and respiratory systems during anesthesia periods. Once anesthesia was induced with propofol at 5.1 ± 0.9 mg/kg, it was maintained with isoflurane at 1%-3% in the first treatment period and sevoflurane at 2%-4% in the second treatment period after a 15-day interval. Heart rates measured immediately after anesthesia induction and 5 min later were found to be statistically significant between anesthetic groups (P < 0.05). Mean blood pressure in the isoflurane group decreased (75.7 ± 7.2 to 59.8 ± 9.8 mmHg) (P < 0.05) throughout the anesthesia period. It was determined that respiratory rate in sevoflurane treatment was lower than that in isoflurane treatment. In terms of time to stand up, sevoflurane-adminis...

Comparison of Clinical and Hemodynamic Effects of Isoflurane and Sevoflurane Anesthesia in Calves

“…In particular, the decrease in the isoflurane group was significant from the 5th min of the anesthesia, compared to the baseline value, whereas it was significant from the 10th min of the anesthesia in the sevoflurane group. These findings were similar to previous studies, where body temperature was reported to decrease in buffalos [6], dogs [9], goats [22] and camels [2] after isoflurane anesthesia, and in dogs [9], cattle [14] and goats [22] after sevoflurane anesthesia. In the current study, regarding body temperature, there were no significant differences between isoflurane and sevoflurane anesthesia.…”

Ankara keçilerinde ovariektomi operasyonlarında tiopental-sevofluran ile tiopental-isofluran’ın kardiyovasküler sistem üzerine etkilerinin karşılaştırılması

“…Isoflurane and sevoflurane increase the heart rate in dogs, goats [3,4,12,13], whereas the heart rate remains unchanged in horses and calves [14,15]. Contrary to dog and goat, the rate generally decreases in cat, sheep and lambs [6,16,18].…”

“…Isoflurane and sevoflurane cause a dose dependent decrease in blood pressure, cardiac output and systemic vascular resistance in goats, dog, horse and sheep [3][4][5]19]. SABP, DABP and MABP values are decreased in dog, horse, goat [12][13][14]. SABP and DABP values increased under isoflurane and sevoflurane anaesthesia in sheep, but these changes were insignificant between isoflurane and sevoflurane groups [6].…”

“…Sevoflurane and isoflurane can cause a dose dependent decrease in RR in dogs, horses, sheep and goats [12][13][14]19].…”

“…In previous studies, the time to standing was shorter for sevoflurane than isoflurane anaesthesia in horse, sheep, calf, lamb, goat and dog [3,4,13,[20][21][22]. It was reported that sheep were extubated in 6.37 and 7.66 minutes when anaesthetized with isoflorane and sevoflurane, respectively [6].…”