The present data confirm that PA and MEC are the most common benign and malignant SGTs. However, it is important to consider that differences in tumor types may be influenced by whether a tumor derives from a medical or a dental service.

A significant association between the BD model and outcome of OSCC patients was observed, indicating this new histopathological grading system as a possible prognostic tool.

Previous studies have shown loss of heterozygosity (LOH) at the BRCA1 and FHIT genes in sporadic primary breast cancer. The aim of this study was to evaluate concomitant LOH at the BRCA1 and FHIT genes in sporadic breast cancer and investigate its influence on patient survival. Loss of heterozygosity was determined using microsatellite markers. The analysis on the informative cases (n = 72) indicated LOH at both the BRCA1 and FHIT loci in 25 cases (35%), the absence of LOH at both loci in 23 cases (32%), and the presence of LOH at one of the loci in 24 cases (33%). The concomitant LOH was associated with poor prognostic factors, such as large tumors (P = 0.01), axillary nodal involvement (P < 0.01), histologic grade III (P < 0.01), vascular invasion (P = 0.01), and negative hormone receptor (P = 0.02). After a median follow-up period of 48 months, the concomitant LOH group had the shortest survival (P < 0.02 by log-rank test; P < 0.05 by Cox model; hazard ratio of 4.87), compared with patients without LOH. These data suggest that concomitant allelic losses of the BRCA1 and FHIT genes are associated with more aggressive breast tumors.

the Helicobacter pylori in this association being discovered at the end of the last century by Marshall and Warren. Since then, studies have related H. pylori to several gastric illnesses, including gastric cancer [1,2]. The eradication of this bacteria is one of the subjects most studied in this regard [3,4]. Most of the published studies are about the eradication of H. pylori in nonoperated stomachs; however, there are few references to this eradication in gastrectomized patients; in particular, in those with a Roux-en-Y diversion [5]. As far as we know the efficacy of antibiotics for the eradication of H. pylori depends on several factors: the gastric pH, the level of drug in the gastric mucosa, and acquired resistance [6]. These factors could explain some of the alterations that occur in the efficacy of H. pylori eradication when medications are used in patients with a partially removed stomach.The cause of gastric stump cancer is multifactorial, and H. pylori seems to be one of these factors [7]. The eradication of H. pylori decreases the risk of the development of gastric stump cancer [8]. Therefore, it is considered of fundamental importance to carry out a clinical study that could verify the efficacy of a triple therapy regimen in gastrectomized patients. This study was carried out to compare the efficacy of H. pylori eradication with a triple therapy regimen (clarithromycin, amoxicillin, and lansoprazole) in gastrectomized and nongastrectomized patients, having as an hypothesis that there could be alterations in the efficacy of the treatment (due to the physiological and anatomical differences of the gastrectomized stomach), which could mean that a new therapeutic regimen would be needed. AbstractBackground. The cause of cancer in the gastric stump is multifactorial, and Helicobacter pylori is one of these factors. Its eradication has been recommended; however, there are few studies about of H. pylori eradication in gastrectomized patients. Methods. Twenty gastrectomized patients with gastric adenocarcinoma and Roux-en-Y reconstruction (study group) infected by H. pylori were compared with nongastrectomized patients (control group) also infected by H. pylori. The presence of H. pylori was determined by the ultra-quick urease test and from a histological sample obtained by endoscopy. Both groups received the same triple therapy regimen. Results. The rate of eradication of H. pylori in the study group was 90% and in the control group, it was 85%. Sex, age, and postoperative time did not influence the rate of eradication. Conclusion. There were no differences in the efficacy of H. pylori eradication between the two groups; therefore, the triple therapy regimen is effective for the eradication of H. pylori in gastrectomized patients with a Roux-en-Y reconstruction.

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