BACKGROUND: Cheilitis is an inflammatory disease of the lips, its red border, mucous membranes, and skin. There are meteorological, actinic, hypo-, and avitaminosis cheilitis, according to medical indications. Classification of cheilitis includes many types of diseases and is somewhat conditional. For these types of cheilitis treatment are most appropriate to use biologically active substances, in particular lipophilic extract of bee pollen. Lipophilic extract of bee pollen is a complex, concentrated plant-bee product with unique consumer and medicinal qualities. It should be noted that experiments have shown that the bee pollen lipophilic extract has a reparative effect higher than the widespread sea buckthorn oil. AIM: The aim of the work is to create therapeutic and prophylactic cream with lipophilic extract of bee pollen for the cheilitis treatment and prevention. MATERIALS AND METHODS: Cream preparation was conducted by phase inversion. Thermal and colloidal stability, pH values, the quantitative content of carotenoids, viscosity, osmotic activity, and microbiological purity were determined by generally accepted methods. RESULTS: Samples of the cream containing lipophilic extract of bee pollen are a homogeneous mass of soft consistency with light yellow color and pleasant specific odor. In estimating, the thermal stability cream samples cheilitis curing were successfully tested and proved to be stable. When centrifuging, the absence of stratification of the cream into fatty and aqueous phases after the test has showed the stability of the cream. The pH of the cream samples corresponds to the pH of the skin. During a qualitative test green color indicates the presence of carotenoids. Quantitative determination of the carotenoids amount in the cream for treatment and prevention cheilitis (in recalculation to β-carotene) corresponds to the set content of carotenoids in the cream of 5.4 mg. The viscosity of the developed cream at 16.2 s−1 is 68.38 ± 0.21 Pa x s, that fully corresponds to the viscosity of creams. In the study of osmotic activity, it was found that the cream with a glycerol content of 7% provides moderate osmotic activity of the drug for 8 h, which may indicate the absence of overdrying and irritating effect. In terms of microbiological purity, the investigated cream with lipophilic extract of bee pollen meets the requirements of the State Pharmacopoeia for finished medicines for topical use (category 2). CONCLUSION: For the cheilitis treatment and prevention has suggested the composition of the cream which contains biologically active substance – lipophilic extract of bee pollen. The technology of the cream with lipophilic extract of bee pollen was developed. Thermal and colloidal stability, pH values were studied; the quantitative content of carotenoids, viscosity, osmotic activity, and microbiological purity was determined. The research carried out made it possible to make sure of the correctness and rationality of the developed technology of the cream for the treatment and prevention of cheilitis.
Improving the quality of education is one of the most important tasks facing the teacher. An indicator of the effectiveness of training is its compliance with conditions in which the future specialist will work. University graduates often face the difficult task of adapting the knowledge gained in the learning process to the realities of the workplace. Teachers of the National University of Pharmacy, in particular those who work at the Drugs Technology Department, try to introduce into the educational process classes in which applicants of higher education can see and participate in the work of modern pharmacies. The purpose of such classes is to increase the interest of applicants of higher education in training, demonstration and practice of using modern equipment, increase the efficiency of teamwork and others. The publication presents the experience of conducting classes on the preparation of emulsions using modern equipment with the participation of pharmacy staff who prepare extemporaneous medicines. To compare the efficiency of modern devices, applicants of higher education were divided into two groups, which prepared the emulsion by classical technology and using a homogenizer “Silent Crusher-M”. The result of this lesson is to increase the interest of applicants of higher education in the use of modern telecommunications equipment and devices, increase interest in obtaining theoretical knowledge due to the clarity of their practical implementation, increase awareness of professional development. Applicants for higher education were able to compare the effectiveness of the use of mechanization for the preparation of medicines; the need to acquire skills for further work in the pharmaceutical field, which increases their responsibility to learn.
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