The potential of particle therapy due to focused dose deposition in the Bragg peak has not yet been fully realized due to inaccuracies in range verification. The purpose of this work was to correlate the Bragg peak location with target structure, by overlaying the location of the Bragg peak onto a standard ultrasound image. Pulsed delivery of 50 MeV protons was accomplished by a fast chopper installed between the ion source and the cyclotron inflector. The chopper limited the train of bunches so that 2 Gy were delivered in [Formula: see text]. The ion pulse generated thermoacoustic pulses that were detected by a cardiac ultrasound array, which also produced a grayscale ultrasound image. A filtered backprojection algorithm focused the received signal to the Bragg peak location with perfect co-registration to the ultrasound images. Data was collected in a room temperature water bath and gelatin phantom with a cavity designed to mimic the intestine, in which gas pockets can displace the Bragg peak. Phantom experiments performed with the cavity both empty and filled with olive oil confirmed that displacement of the Bragg peak due to anatomical change could be detected. Thermoacoustic range measurements in the waterbath agreed with Monte Carlo simulation within 1.2 mm. In the phantom, thermoacoustic range estimates and first-order range estimates from CT images agreed to within 1.5 mm.
The performance of prototypes for the ALICE electromagnetic sampling calorimeter has been studied in test beam measurements at FNAL and CERN. A 4 × 4 array of final design modules showed an energy resolution of about 11% / p E(GeV) ⊕ 1.7 % with a uniformity of the response to electrons of 1% and a good linearity in the energy range from 10 to 100 GeV. The electromagnetic shower position resolution was found to be described by 1.5 mm ⊕ 5.3 mm / p E(GeV). For an electron identification efficiency of 90% a hadron rejection factor of > 600 was obtained.
Übersicht: Das Sexual Desire Inventory (SDI-2, Spector et al. 1996) ist bislang eines der wenigen evaluierten Fragebogeninstrumente, die sich gezielt mit dem Konstrukt des sexuellen Verlangens auseinandersetzen. Die vorliegende Arbeit untersucht anhand einer Stichprobe von 156 Studierenden die psychometrischen Eigenschaften einer Kurzversion in deutscher Sprache. Hierzu wurde das Inventar ins Deutsche übersetzt und den Teilnehmern zweimal im Abstand von 14 Tagen vorgelegt. Mithilfe von Item-, Faktoren-und Reliabilitätsanalysen wurde die gekürzte Version des SDI-2 auf ihre Zuverlässig-keit und Dimensionierung hin überprüft. Die 2-Faktorenlösung der englischen Originalversion konnte im Wesentlichen bestätigt werden. Die beiden Faktoren "Verlangen mit Interaktion" und "Verlangen ohne Interaktion" klä-ren 65,1 % der Varianz auf. Die interne Konsistenz der Subskalen und des Gesamttests lag zwischen α = .78 und α = .87. Der Retest-Reliabilitätskoeffizient reichte von r tt = .76 bis r tt = .83. Die Ergebnisse legen nahe, dass es sich bei sexuellem Verlangen um ein zweidimensionales Konstrukt handelt, das sich anhand der Kurzversion des SDI-2 im deutschsprachigen Raum zuverlässig und effizient erfassen lässt.Schlüsselwörter: Faktorenanalyse; Fragebogen; Psychometrie; Reliabilität; sexuelles VerlangenIn der Sexualforschung existieren derzeit viele Fragebogeninstrumente insbesondere aus dem angloamerikanischen Sprachraum. Ein Großteil dieser Fragebögen ist mittlerweile auch ins Deutsche übersetzt und evaluiert. Schwerpunktmäßig wurden in den letzten Jahren deutschsprachige Inventare zur Diagnose von sexuellen Störungen mit zufriedenstellenden Gütekrite-
Abstract. The authors are expanding the capabilities of the SHARP microscope by implementing complementary imaging modes. SHARP (the SEMATECH High-NA Actinic Reticle Review Project) is an actinic, synchrotron-based microscope dedicated to extreme ultraviolet photomask research. SHARP's programmable Fourier synthesis illuminator and its use of Fresnel zoneplate lenses as imaging optics provide a versatile framework, facilitating the implementation of diverse modes beyond conventional imaging. In addition to SHARP's set of standard zoneplates, we have created more than 100 zoneplates for complementary imaging modes, all designed to extract additional information from photomasks, to improve navigation, and to enhance defect detection. More than 50 new zoneplates are installed in the tool; the remaining lenses are currently in production. We discuss the design and fabrication of zoneplates for complementary imaging modes and present image data, obtained using Zernike phase contrast and different implementations of differential interference contrast (DIC). First results show that Zernike phase contrast can significantly increase the signal from phase defects in SHARP image data, thus improving the sensitivity of the microscope. DIC is effective on a variety of features, including phase defects and intensity speckle from substrate and multilayer roughness. The additional imaging modes are now available to users of the SHARP microscope.
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