During radiotherapy treatment for cervical cancer, up to 84% of patients exhibit some form of acute radiation toxicity (ART). The primary aim of this clinical study is to determine the impact of angiotensin-converting enzyme (ACE) inhibitors, β-blockers and other risk factors such as the patient’s anatomical characteristics on ART emergence in patients with locally advanced cervical cancer treated by chemoradiotherapy. This is a combination of two nested case–control studies within the cohort of patients with locally advanced cervical cancer based on the analysis of potential risk factors for the onset of ART in patients treated with 3D conformal radiotherapy (3D-CRT) and 2D conventional radiotherapy (2D-RT), prospectively followed up from January 2017 to September 2018 in a tertiary care hospital. The ACE inhibitors and bladder volume were identified as factors that significantly affect the occurrence of ART in patients treated with 3D-CRT. In patients treated with 2D-RT, the factors that significantly affect the occurrence of ART were ACE inhibitors, body mass index (BMI), brachytherapy rectal and bladder dose. This study has shown that BMI, radiation dose received by the bladder and rectum are of exceptional importance for the occurrence of the ART and also that therapy with ACE inhibitors was associated with the decreased chances of the ART.
Concept of political tolerance is problematized in this paper. By emphasizing the complexity and multidimensionality of this concept, the authors point out that more attention should be devoted to its operationalization in domestic research. Therefore, this paper focuses on the more precise definition of political tolerance and its sociological determinants. In the discussion, the authors examine the methodology and the results of one of the most important survey of political tolerance in the Republic of Serbia.
INTRODUCTION:To define indications for adjuvant radiotherapy in patients with endometrial cancer, the risk groups have been established according to clinical and pathological prognostic factors. The purpose was to determine precise criteria for adjuvant radiotherapy and identify patients with increased risk for disease relapse who may benefit from postoperative radiotherapy, with an acceptable level of toxicity. MATERIALS AND METHODS: A retrospective study was conducted at the Department of Oncology and Radiology, Kragujevac, during a 5-year period. A group of 80 patients with endometrial cancer treated with adjuvant radiotherapy were included in the study. Patients were divided into four risk groups according to ESMO-ESGO-ESTRO Consensus Conference classification. The Kaplan-Meier method was used for overall and progression-free survival. A statistical analysis was performed using SPSS 20.0 statistical software. RESULTS:The 5-year survival rate was 80%, and 66.3% patients were progression-free during this period. Fatal outcome occurred in 20% of patients. The results showed survival was shortest in patients from the high-risk group. Factors that had impact on the 5-year survival were comorbidities, FIGO stage, postoperative radiotherapy, organ site of late toxicity, and localization of metastases. The analysis of postoperative radiotherapy effects showed that 72.5% of patients had no complications. The most common symptoms of late irradiation toxicity arose from the gastrointestinal tract. Toxicity was usually moderate. CONCLUSIONS: Adjuvant radiotherapy can potentially prolong survival and prevent recurrence, with acceptable level of toxicity, to preserve patient's quality of life. Patient classification into appropriate risk groups allows for adjuvant treatment individualization.
We could define disgust as a feeling of revulsion arising as a response to an aversive stimulus, that induces motivation to withdraw from that stimulus. There are several instruments to measure disgust sensitivity and the most used one is the disgust elicitor inventory, the Disgust Sensitivity Scale. It is the aim of this study to validate the translation of the mentioned scale into Serbian language. The sample used for this study numbered 724 participants out of which 513 (70.9%) declared themselves female, and the average age of the participants was 28.3 (SD=6.9) ranging from 18 to 66 years. The sample was collected via an internet survey. The test battery additionally consisted out of the Depression, Anxiety and Stress Scale (DASS21) and the Patient Health Questionnaire 15 (PHQ15). We tested several scale structure models, including the one, three, five and six factor models proposed in various translations and iterations of the scale. None of them proved to achieve adequate model fit criteria in confirmatory factor analysis, but the 6-factor model has the best metrics. However, the subscales in this model have low internal consistency. We have detected an expected gender difference in summary scores. There are almost no significant correlations with any other measured constructs, casting further doubt on the scale. The scale has good temporal stability. We recommend using this scale with caution and using only the summative score, our research confirms the ever-growing body of work showing that elicitor-based disgust sensitivity scales are heavily influenced by the sociocultural environment and are difficult to replicate cross-culturally. A creation of a culture specific elicitor-based disgust sensitivity scale is probably the best solution for the measurement of this construct.
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