Context: Adverse drug reactions represent one of the leading causes of hospitalization and death. Aims: To characterize adverse reactions due to antibiotics and nonsteroidal anti-inflammatory drugs in outpatients over 18 years of age. Methods: Cross-sectional descriptive observational study. It included outpatients aged 18 years or older who went to public health care centers and who presented a health problem, for which they were treated with antibiotics or nonsteroidal anti-inflammatory drugs (NSAIDs). The information was collected through an adaptation of the adverse drug reaction (ADR) report format in outpatients. Results: A sample of 4,573 participants was obtained, of which 556 (12.4%) people presented adverse drug event, 550 ADR were detected by NSAIDs and antibiotics, of which, 51.4% (291) were classified according to Naranjo’s algorithm as probable, 37.8% (214) as possible and 8.0% (45) as defined. According to the Rawlins and Thompson classification the majority were type A with 413 (75.1%). The severity was mostly mild, with 471 (85.6%) and the manifestations of the digestive system predominated with 440 (80.0%). Conclusions: It is necessary to promote and strengthen pharmacovigilance activities, as well as the training and updating of health personnel in the detection of ADR, since in many cases these can be avoided, contributing to patient safety and the reduction of public spending on health, especially in low-income countries.
La displasia fibrosa es una enfermedad benigna del hueso, de base genética y de progresión lenta, que se caracteriza por el reemplazo progresivo del hueso normal por tejido fibrótico. El proceso puede afectar un solo hueso o múltiples huesos (displasia fibrosa monostótica o poliostótica); esta última puede estar asociada con enfermedades sindrómicas, como el síndrome de McCune-Albright. Objetivo Revisar el diagnóstico y tratamiento de los pacientes con displasia fibrosa craneofacial. Materiales y métodos Se realizó una revisión de artículos científicos, en revistas indexadas en línea como técnica para la recolección de información relevante en bases de datos como Scielo, Google Académico, Scopus, PubMed, y Dynamed, con artículos publicados en inglés y español. El periodo de revisión tuvo como límite el 01 de junio de 2020. Los términos de búsqueda fueron: “displasia fibrosa”, “displasia fibrosa monostótica”, y “displasia fibrosa craneofacial”. Obteniéndose 33 artículos. Conclusión La displasia fibrosa monostótica craneofacial es una enfermedad rara, que afecta principalmente la mandíbula, el hueso maxilar y el cornete inferior. Puede cursar asintomática o presentar deformidades faciales, dolor y trastornos visuales. Su diagnóstico es principalmente por estudios de imágenes y la biopsia. El tratamiento quirúrgico debe de ser bien planeado en cada uno de los pacientes, enfocado a deformidades faciales, evitar los trastornos visuales y es necesario cuando se maligniza la lesión.
Context: Inappropriate self-medication is seen as a global public health concern. Without appropriate professional healthcare guidance, a variety of issues can arise with potentially serious consequences to one’s personal health. Aims: To describe self-medication in outpatients aged 18 years or over who attended public health care centers in Honduras. Methods: A sample of 4573 people was chosen using a cluster sampling technique. A structured questionnaire was applied. Study variables included: sociodemographic factors, frequency and reasons for self-medicating, kind of medicine and sources of acquisition. Results: With a minimum age of 18 years and a maximum age of 94 years, women predominated with 3340 (73.0%), originated from the department of Francisco Morazán with 1186 (25.9%) persons, primary complete in 1042 (22.8%) persons, and with a monthly household income of less than $171.41 in 1462 (32.0%) persons, 3035 (66.4%) people reported knowing what self-medication is, but 2365 (51.7%) of them were unaware of the consequences of self-medication and 2385 (52.2%) people used medications in the last three months without a prescription. Conclusions: The frequency of self-medication in the studied population shows the need to implement national prevention and promotion initiatives in the rational use of medicines, emphasizing the consequences of self-medication, as well as the creation of stricter surveillance and regulation policies in the sale of medicines.
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