Solitary fibrous tumour of the liver is an extremely rare neoplasm, the reported imaging features of which are largely non-specific. We present a case in which dynamic contrast-enhanced CT, MRI and diffusion-weighted MRI findings suggested a diagnosis of solitary fibrous tumour of the liver that was subsequently confirmed by immunohistochemical evaluation.
OBJECTIVEThe aim of this study is to find a correlation between pleural separation and amount of aspirated effusion. METHODSTotal 20 adult patients with 25 effusions were taken into the study with chest x-ray showing homogeneous opacity in either one or both of the lung field, which was confirmed on USG. Only uncomplicated pleural effusion were taken into study. Effusion with septations or encysted effusion or pyothorax were excluded from the study. RESULTSThe separation between two pleura was measured in millimeters and aspirated effusion in milliliters. A positive correlation was noted between these two measurements and relationship is given by a simplified equation. CONCLUSIONBy using this simple equation, we can quantify the pleural fluid quickly in day-to-day practice as well as ICU setting, which can be a useful guide for planning and management for aspiration. CONSENTAs all the patients were adult and fully conscious, informed consent was taken from all of them.
Objective: The research work unveils the use of nuclear magnetic resonance (NMR) technique for quantitative determination and method validation of obeticholic acid. As standard expository methodology for more up to date medications or formulations may not be available in pharmacopeias, hence it is fundamental need to create novel analytical procedures which should be precise and accurate. Methods: Proton (1H) and carbon (13C) NMR analysis were initially performed to confirm the preliminary authenticity of obeticholic acid API. Method validation was accomplished on the basis of standard guidelines for the parameters, in which tetramethylbenzene as an internal standard and deuterated dimethyl sulfoxide as a diluent were used to assess the obeticholic acid. Results: For the quantification of the drug, the proton nuclear magnetic resonance signals at 0.602 ppm and 6.86 ppm corresponding to the analyte proton of drug and internal standard respectively were used. The curve equation calculated from the regression method, the relative-standard-deviation and correlation-coefficient were found to be 0.743% and 0.9989 respectively, indicating good linearity. Consequently, the quantitative assay of the drug was found to be 99.91% in linearity with limit of detection and quantification values as 0.0773 mg and 0.2344 mg respectively, making successful the study of method validation for obeticholic acid. Conclusion: The advantage of the method was that no reference standard of analyte drug was required for quantification and method validation. The method is non-destructive and can be applied for quantification of drug in commercial pharmaceutical formulation products.
Introduction: Cervical spondylosis is a common degenerative condition of the spine that is on a rise. Owing to the chronic pathology of the condition, the proprioceptive and kinaesthetic receptors are affected. Appropriate and accurate response to various stimuli in the space requires timely reactions. Due to the changes in these receptors, reaction time maybe prolonged in individuals.Objectives: To determine simple reaction time in individuals with cervical spondylosis and normal. To compare the simple reaction time among the normal and cervical spondylosis subjects.Material and methods: Design-Experimental study on 50 individuals with cervical spondylosis and 50 normal subjects between the ages of 30-50yrs of age. Materials-A computer software that is the deary liewald reaction time task (Version-3.1, Reliability-0.94) to measure simple reaction time (SRT). Two practise trails and 20 real time reaction was collected in ms and used for statistical analysis.Results: There was a significant statistical difference in the mean reaction time between the normal (290.72ms) and cervical spondylosis (486.78ms) individuals using Unpaired t-test (p<0.05). Conclusion:The study concluded that there is a significant increase in the simple reaction time of cervical spondylosis individuals
Case reportA four month old baby girl was brought to our department with a history of progressive decrease in movements of the left lower limb of three weeks duration and right lower limb of one day duration. The baby was intermittently febrile since three days prior to hospital admission and also had retention of urine of one day duration. The baby did not have any seizures, altered sensorium, vomiting or any history suggestive of central nervous system (CNS) involvement or raised intracranial tension. Parents noticed decreased sensations in lower limbs. The mother also reported that when pinched on the left leg she was not wincing or crying. She had a birth mark with a dimple in the lower back from which a recurrent discharge of white fluid was present since one and a half months of age. The parents had consulted multiple doctors including a neurosurgeon for the same but was reassured and sent back.On examination at the time of admission, the baby was conscious and alert, but irritable. The cranial nerves and upper limbs were normal. She had dorsolumbar scoliosis with convexity to the left, lax anterior abdominal wall on the left side and flaccid anal sphincter. There was a pale pink patch (3×3cm) with a central dimple in the lumbosacral area, approximately 3.5cm above the gluteal cleft suggestive of a congenital dermal sinus with neuro-_________________________________________ The authors declare that there are no conflicts of interest Personal funding was used for the project. Open Access Article published under the CreativeCommons Attribution CC-BY License.cutaneous marker (Figure 1). Her lower limbs were hypotonic with complete paralysis (power 0/5). Bilateral knee jerks, ankle jerks and plantar responses were absent. There was no response to pain in the lower extremities. Laboratory investigations showed leucocytosis with neutrophilia (White blood cell count 23,000/µL with 60% neutrophils) and elevated C-reactive protein (22.5 mg/L; normal <5 mg/L). X-ray of lumbosacral spine showed dorsolumbar scoliosis. Magnetic resonance imaging (MRI) of spine showed absent posterior elements at S1 and S2 with tethered cord and enlarged conus. There was an intramedullary abscess extending from D3 to S2 with a sinus tract extending to the skin from the thecal sac attached to the conus (Figure 2).She underwent L3 to S2 laminoplasty with excision of the dermal sinus. The intramedullary abscess was evacuated and the tethered cord released (Figure 3). An epidermoid tumour associated with the CDS noticed intraoperatively was also excised (Figure 4).
OBJECTIVE: Cerebral hydatid disease is very rare, representing only 2% of all cerebral space occupying lesions even in the countries where the disease is endemic. The aim of this paper is to describe the characteristic features of cerebral hydatid disease in computed tomography (CT) and magnetic resonance imaging (MRI). METHODS: Here is a case 25yr/m who presented to neurosurgery OPD with complaints of headache, vomiting, right sided weakness and seizures for 2 weeks. CT and MRI were the imaging modalities to reach the diagnosis which was pathologically confirmed postoperatively as hydatid disease. RESULTS: CT and MR imaging findings of E. granulosus lesions were well defined, smooth thin-walled, spherical, homogeneous cystic lesions with no contrast enhancement, no calcification, and no surrounding oedema. CONCLUSION: Although cystic cerebral hydatid disease is well demonstrated by CT and MR examinations, CT is superior in detecting calcification in the cyst, when present, MR is better in demonstrating cyst capsule, detecting multiplicity and defining the anatomic relationship of the lesion with the adjacent structures, and it is more helpful in surgical planning.
No abstract
Methods Retrospective analysis of the first 75 diagnostic cerebral angiograms performed with dTRA by a single operator was performed. Outcomes included time for sheath insertion, sheath to first vessel time, procedure duration, fluoroscopy time, radiation dose, and contrast volume. Their associations with procedure number were evaluated with multivariate linear regressions, segmented linear regression, and locally weighted regression (LOESS). Results The mean age was 56.1 years and 61.3% were female. 74 of 75 angiograms were successfully completed with dTRA. There were 3 minor and no major complications. After adjusting for covariates, sheath to first vessel Abstract E-098 Table 3 Coiling only vs ballon assissted coiling for ruptured ACoA Aneurysms
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