The aim of this study was to evaluate the effect of Aegle marmelos aqueous extract (AMAE) leaves on obese rats. Twenty-five adult male albino rats (Sprague-Dawley strain), weighing about (200±10g) were divided randomly into two main groups as follow: the first group (-Ve control= 5 rats) was fed on basal diet. The second group (20 rats) was fed on high fat diet (HFD) for 4 weeks then divided equally to 4 groups from group 2 to group 5. Group 2 (+Ve control) fed on basal diet. Group 3, 4 and 5 fed on HDF administrated orally with 1, 2 and 3 ml of AMAE, respectively. At the end of the experimental period (4 weeks), rats were scarified and serum was collected to determine levels of lipid profile, glucose, leptin kidneys and liver functions. The results showed that the body weight of rats and serum levels of lipids profile, leptin, glucose, kidneys functions and liver enzymes were elevated by HFD administration (positive control group) compared with negative control group, while HDL-C decreased. It was also found that oral administration of AMAE diet with reversed these changes that caused by HFD.
A peptic ulcer is sore on the lining of the stomach or duodenum; the two most common types of peptic ulcer are celled gastric ulcer and duodenum ulcer. Peptic ulcer are found to be due to an imbalance between aggressive factor such as hydrochloric acid (HCL), pepsin and refluxed bile. As the current study aimed to investigate the protective effect of Licorice against peptic ulcer.Thirty male Wistar albino rats were randomly divided into five groups (n = 6) as follow; -ve control group fed basal diet, +ve control group fed basal diet and injected with a single dose of Ranitidine (20mg/kg/day, bw, p.o.) (7 days). Groups 3-5 fed licorice with 1 ml. once a week, 1 ml. twice a week, 1 ml. three times a week respectively. Results revealed that licorice caused a significant decrease in blood cholesterol level, TG, LDL, AST, ALT, urea nitrogen, uric acid, creatinine, uric acid, albumin and VLDL. In addition, licorice caused a significant increase in HDL and PH, especially in group 5 which fed 3 ml. compared to +ve control group.
This study aimed to evaluate the effect of dried figs with high content of antioxidants namely fig (Ficus carica L) on lowering blood cholesterol in hypercholesterolemic rats. Vitamins A and C, total polyphenols and total flavonoids were determined in figs in fresh fruits and after being dried. All these antioxidants were found in considerable amounts in fig. Thirty male albino rats were divided into six groups 5each, the first group received a standard and served as a negative control, and the second group received a hypercholesterolemic diet and served as a positive control. Group 4 was the protective group that fed on a higher percentage of figs 6% and the other three groups received a hypercholesterolemic diet containing different levels from fig (2, 4 and 6%) for 8 weeks. At the end of this period, blood was withdrawn after overnight fasting and biochemical parameters were analyzed. Serum total cholesterol, serum triacylglycerol (TG), serum low density lipoprotein cholesterol (LDL-C), serum very low density lipoprotein cholesterol (VLDL-C), serum high density lipoprotein cholesterol (HDL-C) and atherogenic index (LDL-C/HDL-C) were estimated. Also, the activity of the liver enzymes ALT and AST were determined. A histopathological examination of the aorta was done.
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