bioactive role of aqueous extract of aegle marmelos leaves on obese rats

Abstract

The aim of this study was to evaluate the effect of Aegle marmelos aqueous extract (AMAE) leaves on obese rats. Twenty-five adult male albino rats (Sprague-Dawley strain), weighing about (200±10g) were divided randomly into two main groups as follow: the first group (-Ve control= 5 rats) was fed on basal diet. The second group (20 rats) was fed on high fat diet (HFD) for 4 weeks then divided equally to 4 groups from group 2 to group 5. Group 2 (+Ve control) fed on basal diet. Group 3, 4 and 5 fed on HDF administrated orally with 1, 2 and 3 ml of AMAE, respectively. At the end of the experimental period (4 weeks), rats were scarified and serum was collected to determine levels of lipid profile, glucose, leptin kidneys and liver functions. The results showed that the body weight of rats and serum levels of lipids profile, leptin, glucose, kidneys functions and liver enzymes were elevated by HFD administration (positive control group) compared with negative control group, while HDL-C decreased. It was also found that oral administration of AMAE diet with reversed these changes that caused by HFD.