Introduction The involvement of mucin, lectin, and apoptosis in colitis is still unclear. This study aimed to investigate changes in MUC2 expression, inflammation, and changes in lectin expression in colitis patients. Methods A total of 17 patients were divided into two groups including 11 hemorrhoid patients as a control group and 6 colitis patients. MUC2 mutation analysis was carried out using immunofluorescent and FISH techniques. Assessment of caspase-3, Ki-67, NF-kB, and lectin expressions was also carried out by immunofluorescent technique then analyzed by confocal laser scanning microscope. Results The MUC2, caspase-3, and lectin expressions were significantly lower in the colitis group than in the control group (p < 0.05). Conclusions It was concluded that in colitis there was a change in MUC2 expression due to changes in lectins accompanied by apoptotic defects.conclusion
Colorectal cancer is a malignancy of epithelial cells of the colon or rectum. Factors associated with an increased risk of this type of cancer include eating habits. The purpose of this study was to determine distribution the dietary patterns in colorectal cancer patients at hospitals Ulin Banjarmasin period from August to October 2015 by a review of fat dietary, protein dietary, fiber dietary by age and gender. This research is a descriptive observasional with cross sectional approach. Data was collected using a food frequency questionnaire and interviews. Sampling was conducted with consecutive sampling technique to obtain the sample amounted to 30 patients in accordance with the inclusion criteria. Obtained the age group of patients when first diagnosed with colorectal cancer is highest in the age group 41-60 years (50%) as many as 15 people. Sex ratio of colorectal cancer patients in hospitals Ulin Banjarmasin the period August-October 2015 that men of 15 people (50%) and women of 15 people (50%). Of the 30 respondents, there are 28 (93.4%) patients with colorectal cancer who rarely consume fat, there are 25 (83.4%) patients with colorectal cancer who rarely consume protein, and there were 25 (88.7%) patients with colorectal cancer are rare consuming fiber. Distribution of pattern dietary (fat, protein, fiber)by age and sex obtained the same result that most are in the rare category. Keywords: colorectal cancer, fat, protein, fiber. Abstrak: Kanker kolorektal adalah suatu keganasan dari sel epitel kolon atau rektum. Faktor yang berkaitan dengan peningkatan risiko kanker jenis ini antara lain kebiasaan makan. Tujuan penelitian ini adalah untuk mengetahui distribusi pola diet pasien kanker kolorektal di RSUD Ulin Banjarmasin periode Agustus-Oktober 2015 dengan tinjauan terhadap diet lemak, diet protein, diet serat berdasarkan usia dan jenis kelamin. Penelitian ini merupakan penelitian yang bersifat deskriptif observasioal dengan pendekatan cross sectional. Data dikumpulkan dengan menggunakan lembar kuesioner food frequency dan wawancara. Pengambilan sampel dilakukan dengan teknik consecutive sampling sehingga didapatkan sampel berjumlah 30 pasien yang sesuai dengan kriteria inklusi. Didapatkan kelompok usia pasien saat pertama kali terdiagnosis kanker kolorektal terbanyak adalah pada kelompok usia 41-60 tahun (50%) yaitu sebanyak 15 orang. Rasio perbandingan jenis kelamin pasien kanker kolorektal di RSUD Ulin Banjarmasin periode Agustus-Oktober 2015 yaitu laki-laki sebanyak 15 orang (50%) dan perempuan sebanyak 15 orang (50%). Dari 30 responden, terdapat 28 (93,4%) pasien kanker kolorektal yang jarang mengkonsumsi lemak, terdapat 25 (83,4%) pasien kanker kolorektal yang jarang mengkonsumsi protein, dan terdapat 25 (88,7%) pasien kanker kolorektal yang jarang mengkonsumsi serat. Distribusi pola diet (lemak, protein, serat) berdasarkan usia dan jenis kelamin didapatkan hasil yang sama yaitu paling banyak berada pada kategori jarang. Kata-kata kunci: kanker kolorektal, lemak, protein, serat
Introduction During the coronavirus disease 2019 (COVID‐19) pandemic, digestive surgery potentially exposes both health‐care professionals and vulnerable patients to COVID‐19. A survey was conducted with aim to determine the digestive surgery services provided during the COVID‐19 pandemic, optimize safety for patients and clinicians, and safeguard health‐care services. Methods An online survey was conceived and circulated to members of the Indonesian Society of Digestive Surgeons. The survey was conducted in two phases, in April 2020 and July 2020, to evaluate changes in response to the COVID‐19 pandemic. Results Early in the pandemic (April 2020), the median number of major digestive surgeries performed monthly declined from 20 cases (range. 3‐100 cases) to 1 case (range. 0‐10 cases) (P < .001; Wilcoxon signed‐rank test). Most of the cases in April 2020 addressed emergency problems, but more definitive surgeries were performed during the later period of the survey. The importance of screening for COVID‐19 with polymerase chain reaction has increased over time, and a more comprehensive screening methodology incorporating real‐time polymerase chain reaction, chest CT, and rapid antibody test were evident in 31.37% of July 2020 responses. Conclusion Our survey has shown that surgeons adapted to the evolving pandemic and continue to do so only with appropriate safety assurances.
Flood disaster is a common problem, especially in densely populated urban, coastal, and basin areas, respectively. This leads to the development of the Mini Polder design, which is used to solve the problem of flooding in agricultural land. The design is projected in lebak swamp in Ampukung village, Tabalong Regency, Indonesia, covering an area of 393 Ha. Therefore, this study aims to determine the hydraulic performance of mini polders in flood management, within Tabalong District, South Kalimantan, Indonesia. Using Hec-RAS in the planning stage, the results showed that a dike was produced with an elevation and a width of +10.30 and 4 m, based on the Q25th flood discharge of 514.37 m3/s. Furthermore, the construction of a channel around the land was planned as a replacement for the retention pond, due to the efficiency of excavation and stockpiling. The channel also functioned as a flood reducer, which approached water sources to the rice fields or community plantations. By excavating the existing outlet and rehabilitating the door building, the channel normalization was subsequently carried out. For emergency conditions, a portable water pump was needed for water supply and disposal of the Tabalong river, during the arrival of the dry season.
Background. Laparoscopic cholecystectomy since long time already has become the preferred method because laparoscopic cholecystectomy has many advantages compared to standard open cholecystectomy. However, since it has associated with a higher risk of complication, preoperative prediction of risk factors is needed to assess the intraoperative difficulties. Various scoring systems have a role in predicting intraoperative difficulties; however, there is a need to find a consistent and reliable predictive system. Aim. To validate a preoperative scoring system that will predict difficult laparoscopic cholecystectomy. Design of the Study. Nonrandomized retrospective descriptive study. Setting. Department of General Surgery, Lambung Mangkurat Univeristy Ulin Referral Hospital, Banjarmasin, Kalimantan Selatan, Indonesia. Methodology. A preoperative score was given to all the patients (134 patients from January 2015–December 2020) based on history, clinical examination, and sonographic findings. Using ROC curve, the cutoff for easy—difficult was 3.5 and difficult—very difficult was 7.5. The scores were compared in each patient to conclude the practicality of the preoperative predictive score. SPSS version 25 was used to analyze the data. Results. History of hospitalization for acute cholecystitis ( p ≤ 0.001 ), high BMI ( p = 0.002 ), abdominal scar ( p = 0.005 ), palpable gallbladder ( p ≤ 0.001 ), thick gallbladder wall ( p ≤ 0.001 ), and leucocyte ( p ≤ 0.001 ) were considered as the significant factors that predict difficult laparoscopic cholecystectomy. Sensitivity and specificity for easy—difficult cutoff of the scoring method were 72.6% and 87.5%, respectively, with the area under the ROC curve being 0.849. Sensitivity and specificity for difficult—very difficult cutoff of the scoring method were 70.0% and 84.5%, respectively, with the area under the ROC curve being 0.779. Conclusion. The preoperative scoring system evaluated in the study is reliable and beneficial in predicting the difficulty of laparoscopic cholecystectomy. However, further randomized prospective multicentric studies with large sample sizes are required to validate the efficiency of the scoring system.
Appendicitis is the most common cause of abdominal pain in digestive surgery and requires immediate surgery to prevent complications. The diagnosis of acute appendicitis that is non-invasive, easy and fast, is using the Alvarado score and then compared with the histopathological picture of the appendix post appendicectomy. This study aims to determine the relationship between the number of polymorphonuclear inflammatory cells and the Alvarado score in acute appendicitis patients at Ulin Hospital Banjarmasin in 2016-2021. This study is an analytic observational study with a retrospective cohort approach, with a sample of 52 people who meet predetermined criteria and were selected by non-probability sampling technique. The data used for this study is the Alvarado score of acute appendicitis patients taken from secondary data and the results of the calculation of the counting of polymorphonuclear inflammatory cells in the form of primary data taken from photos of appendicitis tissue preparations of patients with appendicitis. The Pearson correlation test has shown that there is no relationship between the counting of polymorphonuclear inflammatory cells and the Alvarado score with a p value of 0.339 > 0.05 (p > 0.05). Based on the results of this study, it can be concluded that there is no relationship between the counting of polymorphonuclear inflammatory cells and the Alvarado score in acute appendicitis patients at Ulin Hospital Banjarmasin in 2016-2021. Keywords: acute appendicitis, polymorphonuclear cell (PMN) count, Alvarado score Abstrak: Apendisitis merupakan penyakit penyebab nyeri pada abdomen tersering di bidang bedah digestif dan memerlukan tindakan pembedahan segera untuk mencegah komplikasi. Diagnosis apendisitis akut yang tidak invasive, mudah dan cepat, adalah menggunakan skor Alvarado lalu dibandingkan dengan gambaran histopatologi apendiks post apendiktomi. Penelitian ini bertujuan untuk mengetahui hubungan dari jumlah sel radang polimorfonuklear dengan skor Alvarado pada pasien apendisitis akut di RSUD Ulin Banjarmasin tahun 2016-2021. Penelitian ini adalah penelitian observasional analitik dengan pendekatan kohort retrospektif, dengan jumlah sampel sebanyak 52 orang yang sesuai dengan kriteria yang telah ditentukan dan dipilih dengan teknik non probability sampling. Data yang digunakan untuk penelitian ini adalah nilai skor alvarado pasien apendisitis akut yang diambil dari data sekunder dan hasil perhitungan jumlah sel radang polimorfonuklear berupa data primer yang diambil dari foto preparat jaringan apendiks pasien apendisitis. Uji korelasi Pearson yang dilakukan telah menunjukan tidak adanya hubungan antara jumlah sel radang polimorfonuklear dan skor alvarado dengan nilai p yaitu 0,339 > 0,05 (p > 0,05). Berdasarkan hasil penelitian ini dapat disimpulkan bahwa tidak terdapat hubungan antara jumlah sel radang polimorfonuklear dengan skor Alvarado pada pasien apendisitis akut di RSUD Ulin Banjarmasin tahun 2016-2021. Kata-kata Kunci: apendisitis akut, jumlah sel radang polimorfonuklear (PMN), skor Alvarado
Appendicitis is a disease caused by a blockage in the appendix. In 2009 it was found that at least 596,132 people in Indonesia had acute appendicitis. The diagnosis of appendicitis can be seen based on clinical manifestations, physical examination, and supporting examinations. Scoring is the fastest tool for predicting the diagnosis of acute appendicitis. This study will show whether there are differences in Alvarado scores, modified Alvarado scores, and Kalesaran scores in diagnosing acute appendicitis patients. With an analytical observational study, 66 samples from purposive sampling were processed through a retrospective cross-sectional approach. The inclusion criteria determined were patients aged 18-65 years and patients with physical examination of fever, epigastric diffuse pain, anorexia, nausea and vomiting, lower right tenderness, loose tenderness, Rovsing Sign, Psoas Sign, cough sign, leukocytosis, and displacement neutrophils to the left. With the exclusion criteria of patients with other infections and patients with incomplete data in the morning report. 44% were patients aged 18-25, and 9% were 56-65 years. 63% experienced by men and 38% by women. The most common manifestation was tenderness in the right lower quadrant while the least was fever with a total of 24 people. Data analysis using logistic regression showed P > 0.05 with the conclusion that there was no significant difference between Alvarado, modified Alvarado, and Kalesaran scores in diagnosing acute appendicitis patients. Keywords: acute appendicitis, Alvarado score, modified Alvarado score, Kalesaran Abstrak: Apendisitis merupakan penyakit yang disebabkan oleh sumbatan pada apendiks. Pada 2009 didapatkan setidaknya 596.132 orang di Indonesia mengalami apendisitis akut. Diagnosis apendisitis dapat dilihat berdasarkan manifestasi klinis, pemeriksaan fisik, serta pemeriksaan penunjang. Skoring menjadi alat paling cepat untuk memprediksi diagnosis apendisitis akut. Penelitian ini akan menunjukkan apakah terdapat perbedaan skor Alvarado, skor Alvarado termodifikasi, dan Skor Kalesaran dalam mendiagnosis pasien apendisitis akut. Dengan penelitian observasional analitik, 66 sampel dari purposive sampling diolah melalui pendekatan retrospective cross-sectional. Kriteria inklusi yang ditentukan adalah pasien dengan umur 18-65 tahun dan pasien dengan pemeriksaan fisik demam, nyeri baur epigaster, anoreksia, mual muntah, nyeri tekan kanan bawah, nyeri tekan lepas, Rovsing Sign, Psoas Sign, cough sign, leukositosis, serta perpindahan neutrofil ke kiri. Dengan kriteria eksklusi pasien yang mengalami infeksi lain serta pasien dengan data tidak lengkap pada morning report. 44% merupakan pasien dengan umur 18-25, dan 9% pada 56-65 tahun. 63% dialami oleh laki-laki dan 38% oleh perempuan.manifestasi paling banyak ditemukan adalah nyeri tekan pada kuadran kanan bawah sedangkan paling sedikit adalah demam dengan jumlah 24 orang. Analisis data menggunakan regresi logistik menunjukkan P > 0,05 dengan kesimpulan bahwa tidak ada perbedaan yang signifikan antara skor Alvarado, Alvarado termodifikasi, dan Kalesaran dalam mendiagnosis pasien apendisitis akut. Kata-kata kunci: apendisitis akut, skor Alvarado, skor Alvarado termodifikasi, Kalesaran
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