Background: Currently it is believed that human papillomaviruses (HPV) are associated with the development of some oral/oropharyngeal cancers. It has been suggested that these viruses influence carcinogenesis in both smokers and non-smokers. Data on the prevalence of HPV in healthy adults are thus needed to estimate the risk of oral/oropharyngeal cancer. The aim of this study was to assess the prevalence of oral HPV in healthy female adults in Indonesia and Thailand. Materials and Methods: Healthy female students from the Faculties of Dentistry of Universitas Indonesia and Chiang Mai University were asked to participate in this pilot study. DNA was extracted from saliva specimens and screened for HPV16 and HPV18 using PCR. Results: The age, marital status and sexual experience of the subjects between the two countries were not significantly different. Eight (4%) and 4 (2%) samples were positive for HPV16 and HPV18, respectively. Fisher's Exact test found a significant difference between HPV16 positivity in subjects who were married and had sexual intercourse but not for HPV18. Conclusions: This study successfully detected presence of HPV16 and HPV18 DNA in a number of saliva samples from female dental school students. Marital status, experience of sexual intercourse and safe sexual practice are related to the possibility of finding HPV DNA finding in saliva. Dentists, physicians and other health care professionals may gain significant value from the findings of this study, which provide an understanding of the nature of HPV infection and its risk to patient health and disease.
Several orofacial disorders in patients with end stage renal disease (ESRD) undergoing hemodialysis have been reported. However, up to the present, particularly in Indonesia, such data still limited. Objective: the purpose of this study was to assess the orofacial disorders in patients with ESDR undergoing hemodialysis at Cipto Mangunkusumo Hospital, Indonesia. Methods: The study was conducted through observation using a cross-sectional design. The subjects were selected by consecutive sampling. Ninety-three patients fulfilled the inclusion criteria and enrolled in this study. They participated in the structural interview-using questionnaire assessing subjective complaints; clinical examinations; and salivary measurements. Results: Xerostomia (82.8%) dysgeusia (66.7%), metal taste (57%), perioral anesthesia (24.7%) were the common symptoms. Clinical findings consisted of tongue coating (100%), calculus deposits (97.8%), pallor of oral mucous (94.6%), sialosis (75.3%), uremic odor (40,9%), haemorrhagic spot (39.8%), angular cheilitis (37.7%), gingival bleeding (15.1%), and oral candidiasis (3.2%) were also found. Salivary changes showed the increase of salivary viscosity (86%), pH (80.6%), buffer capacity (76.3%) whereas decrease of mucous hydration level (79.6%) and the flow rates of unstimulated (22.6%) and stimulated (31.2%) whole saliva were observed. Conclusion: The findings of orofacial disorders required attention and further comprehensive management to enhance the quality of life of patients with ESDR. ABSTRAK Kelainan regio orofasial pada GGT pasien gagal ginjal terminal (GGT) yang menjalani hemodialisis. Beberapa kelaian orofasial pada pasien gagal ginjal terminal yang menjalani hemodialisis telah dilaporkan. Namun, sampai saat ini, terutama di Indonesia, data yang ada tentang hal tersebut masih sangat terbatas. Tujuan: Penelitian ini bertujuan untuk mengetahui kelainan orofasial pada pasien GGT yang menjalani hemodialisis di Rumah Sakit Cipto Mangunkusumo, Indonesia. Metode: Desain penelitian adalah studi observasi potong lintang. Subjek penelitian dipilih berdasarkan metode consecutive sampling. Sebanyak 93 pasien yang memenuhi kriteria inklusi merupakan subjek penelitian ini. Subjek berpartisipasi dalam wawancara menggunakan kuesioner yang menanyakan tentang adanya keluhan subjektif, pemeriksaan klinis dan pengukuran saliva. Hasil: Serostomia (82,8%), dysgeusia (66,7%), rasa metal (57%), rasa baal perioral (24,7%) merupakan gejala yang sering ditemukan. Temuan klinis meliputi tongue coating (100%), deposit kalkulus (97,8%), mukosa mulut yang pucat (94,6%), sialosis (75,3%), bau uremik (40,9%), bercak hemoragik (39,8%), angular keilitis (37,7%), perdarahan gingival (15,1%), dan kandidiasis oral (3,2%). Perubahan saliva terkait peningkatan viskositas (86%), pH (80,6%), kapasitas dapar (76,3%). Selanjutnya terjadi pengurangan tingkat hidrasi mukosa (79,6%) dan laju alir saliva tanpa stimulasi (22,6%) dan dengan stimulasi (31,2%). Simpulan: Temuan kelaianan orofasial pada penelitian ini membutuhkan perhat...
Introduction: Pemphigus vulgaris (PV) is an autoimmune disease with vesiculobullous lesions that attack the skin and mucosa including oral mucosa. There are some factors that can trigger the recurrence of PV; one of them is psychological stress. PV is treated using immunosuppressant agents like corticosteroids or other immunosuppressant drugs. Complete remission in PV often hard to achieve because of some trigger factors that is hard to control and systemic disease like diabetes mellitus (DM).
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