Background: Currently it is believed that human papillomaviruses (HPV) are associated with the development of some oral/oropharyngeal cancers. It has been suggested that these viruses influence carcinogenesis in both smokers and non-smokers. Data on the prevalence of HPV in healthy adults are thus needed to estimate the risk of oral/oropharyngeal cancer. The aim of this study was to assess the prevalence of oral HPV in healthy female adults in Indonesia and Thailand. Materials and Methods: Healthy female students from the Faculties of Dentistry of Universitas Indonesia and Chiang Mai University were asked to participate in this pilot study. DNA was extracted from saliva specimens and screened for HPV16 and HPV18 using PCR. Results: The age, marital status and sexual experience of the subjects between the two countries were not significantly different. Eight (4%) and 4 (2%) samples were positive for HPV16 and HPV18, respectively. Fisher's Exact test found a significant difference between HPV16 positivity in subjects who were married and had sexual intercourse but not for HPV18. Conclusions: This study successfully detected presence of HPV16 and HPV18 DNA in a number of saliva samples from female dental school students. Marital status, experience of sexual intercourse and safe sexual practice are related to the possibility of finding HPV DNA finding in saliva. Dentists, physicians and other health care professionals may gain significant value from the findings of this study, which provide an understanding of the nature of HPV infection and its risk to patient health and disease.
Hematologic abnormalities are common in HIV-infected patient, particularly in individuals with more advanced HIV disease. Hematologic abnormalities and their association with HIV-associated oral lesions had been reported. Intravenous drug use has been associated with increased oral lesions too. We reported a case of oral lesions in a 24 years old man HIV-infected intravenous drug users. Poor hematologic status is a risk factor of Oral Candidiasis in HIV-infected person with clinical features appear generally. But clinical feature of Herpes Labialis is not usually because his poor hematologic status. It's concluded that poor hematologic status and transmission of HIV through contaminated needlestick are the high risk factors of oral lesions and appear not usually clinical features in ODHA. Correction of these hematologic abnormalities and appropiately management of oral lesions can minimize the severity and to increase the better quality of life patient.
Reaksi hipersensitivitas obat adalah kondisi patologis yang sering terjadi pada manusia dengan insidensi yang meningkat setiap tahunnya. Stevens Johnson Syndrome (SSJ) adalah salah satu istilah penyakit yang disebabkan oleh reaksi hipersensitivitas tubuh terhadap obat, bakteri, virus, dan bahan kimia. Salah satu obat yang secara luas dilaporkan memicu terjadinya SSJ adalah karbamazepin, obat sintetis yang umumnya digunakan oleh pasien gangguan saraf dan kejiwaan. Dua kasus SSJ karena penggunaan karbamazepin dilaporkan dengan manifestasi klinis yang hampir sama, hanya berbeda dalam derajat keparahan dan patogenesis munculnya manifestasi akibat reaksi hipersensitivitas obat yang dikonsumsi. Perawatan komprehensif bersifat multi-disiplin melibatkan Bagian Kulit Kelamin, Saraf, Penyakit Dalam, Penyakit Mulut dan Ahli Jiwa memberikan kemajuan penyembuhan pada penderita. Menjaga kebersihan mulut, penggunaan obat kumur prednison dan krim topikal acetonid floucinolon untuk bibir memberikan kemajuan pesat penyembuhan intra-oral dari pasien, mendampingi obat sistemik dari disiplin ilmu yang relevan. Sebagai kesimpulan, SSJ dapat disebabkan oleh penggunaan karbamazepin dan menunjukkan manifestasi yang parah. SSJ perlu dikelola secara akurat dengan pendekatan multidisiplin terapi.
Abstract-Congestive Heart Failure (CHF) is a condition where the heart is unable to pump adequate blood to organs and tissues, due to one-part failure so that there is blood pooling in the heart. CHF patient needs more attention by dentist, because oral focus infection can affect patient's heart condition. Furthermore, CHF patient condition can cause various complications, so that dental treatment modification is needed. The objective of this paper is to describe the dentist's role as the medical team in CHF patient management. Two female patients, 25 and 59 years old, were hospitalized at RSCM Jakarta with CHF diagnosis, referred to the Oral Medicine clinic for oral cavity focus infection evaluation and management. Both patients were prepared for heart valve surgery. Clinical examination revealed the presence of oral cavity focus infection and cheilosis. In order to eliminate oral cavity focus infection, scaling and tooth extraction are needed, with patient's systemic condition consideration. Dentist has an important role in patient CHF management. A multidisciplinary approach is required to treat CHF patients to prevent complications and to improve treatment results.
A Controve6ial Crse on th. Ditgtlosfu ofChronic Btlllous Typ€ Mucocutancus Dbetse lnvolving Oral Mucos! (t Case Reponl) A case of chronic bullous type mucoculan€us disease involving oral mucosa was reporled fiom a 56 u"u..o|dmanwithneverhea|edoralulce6andwoundontheperianalskinforthreeyears'Th.rewereal l"J"Jiii"i *"i. "" ,rte limb and back skin and a lesion on nail Painful oral lesion consisted ofmucous "r"r." a.rq""l""ii* ei"givitis and slorjghing area on palale and rongue-The patienl is draheric The llr'r Derianal skin draanosrs was gnnutomarous candidiasis wilh differential diagnosis p€mphiSus vegetans and ;;;;; ";fili;;" ioJ."er. tt. histoparhologic cxamination did nor suppon thos€ disgnosis Aftet se,,eral histopathologic examinations. the latest per-ianal skin diagnosis was lichen planus wirh differenlral ;i;;;;.i;;;;i;#.,' ;asculiris. bowenoid pipulosis and pvoderma sansr€nosum other skrn diagnosrs ""1"-ii""." ."ii,f-re orat diagnosis wai mucous membrane pemphigoid wirh differential diagno\r" ii.r""'i;"", sJ."i:. tyndrome ani erythema multiforme oral hi$opathologic exam ination-showed a sub-eDithelial blisler. whrch supponed mucous membran€ pemphigoid A ltp balm prednisone 5 mg oral tinse il ;;i;;;' ".* given but oral improvemenr srarred aRer blood sugar lelel controlled conclusjon: lr r. ""i'""i t"""" "t'.trt"iskio and oral m;cous lesions are from the same disease or not-Indonesian Jowhal of De;tistry 2006; Edisi Khusus KPPIKG Xlv: I2-16
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