A 17-year-old boy underwent a wide partial mastectomy with axillary dissection for secretory breast cancer, followed by low grade irradiation (30 Gy). There were no axillary lymph node metastases. Hormone receptor assay of the tumor was positive for progesterone and negative for estrogen. There was no local recurrence or sign of dissemination after nearly 5 years. Literature search revealed 21 cases of secretory breast cancer in childhood and adolescence; in only 2 cases was the hormonal status studied. We report an additional case and review the literature.
A review of 100 women over 70 years of age treated for breast carcinoma is reported. The short- and long-term results of treatment were evaluated with a median follow up of 4.7 years. Due to our aggressive approach, only 11% of this group died from breast cancer, and the 5-year survival rate was 51%, including all stages of the disease. The result of this study indicates that elderly women with breast cancer should be treated by surgical methods that offer the best chance of cure, regardless of patient's age.
Each of 30 patients underwent elective laparotomy following administration of a single intravenous dose of amikacin, netilmicin or tobramycin. Therapeutic concentrations of amikacin were achieved in peritoneal tissue in 10/10 patients. Only 13/20 samples from patients receiving the other two antibiotics showed antibacterial activity. Our data suggest that the penetrability of tobramycin (53%) and amikacin (39%) into the uninflamed peritoneal tissue is superior to that of netilmicin (16%).
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