Secretory breast cancer in childhood and adolescence: Report of a case and review of the literature

Serour, Francis; Gilad, Adi; Kopolovic, Juri; Krispin, M

doi:10.1002/mpo.2950200415

Cited by 43 publications

(33 citation statements)

References 18 publications

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“…[18][19][20][21][22][23] Studies have shown that lymph node metastasis is rare in children and teenagers. 9,24,25 In our series, there were two cases (case 2 and 3) with axillary lymph nodes metastases. Both of them were adolescents and had a tumor larger than 20 mm.…”

Section: Discussionmentioning

confidence: 52%

“…A total of 27 cases (including 2 cases from our study, see Table 3) of male patients with secretory breast carcinoma could be identified in the literature. 2,3,6,9,23,[25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44] Most affected patients were children and adolescents with a median age of 27 years. The tumors are usually located subareolarly.…”

Section: Discussionmentioning

confidence: 99%

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Secretory breast carcinoma: a clinicopathological and immunophenotypic study of 15 cases with a review of the literature

Xiao

Yang

et al. 2012

Modern Pathology

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Secretory breast carcinoma is a rare breast cancer with indolent clinical behavior. Recent research showed that secretory breast carcinoma belongs to the phenotypic spectrum of basal-like breast carcinomas. In this study, a clinicopathological and immunophenotypic analysis of secretory breast carcinomas from 15 Chinese patients was conducted. This patient group consisted of 2 males and 13 females, with ages ranging from 10 to 67 years old (median, 36 years old). All patients presented with a painless and firm mass. Tumor size ranged from 10 to 55 mm. Most tumors were located in the outer upper quadrant of the breast. Two patients (2 of 13, 15%) displayed positive axillary lymph nodes. At the microscopic level, the presence of intracellular and extracellular secretory material was the most remarkable feature. Most cases showed mild dysplasia cytologically. All cases were negative for estrogen receptor, progesterone receptor and HER2. The expression rate of the basal-like marker (CK5/6 or epidermal growth factor receptor) was 87% (13 of 15). The basal-like phenotype was identified in 13 cases (87%). Follow-up time ranged from 10 to 55 months (median, 19 months). None of the cases had evidence of recurrence and metastasis. Our study reveals that secretory breast carcinoma is a distinct subset of invasive breast carcinoma, with expression of basal-like markers. It should be noted that secretory breast carcinoma is different from conventional basal-like breast carcinomas. Future studies are required to further understand the prognostic significance of the basal-like markers expression in secretory breast carcinomas.

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Section: Discussionmentioning

confidence: 52%

Section: Discussionmentioning

confidence: 99%

Secretory breast carcinoma: a clinicopathological and immunophenotypic study of 15 cases with a review of the literature

Xiao

Yang

et al. 2012

Modern Pathology

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“…The reported female to male ratio is 6:1, [1,9] and SBC has been reported in almost every age group. As was demonstrated by this case, the for GATA3 which is consistent with a breast primary but could also be present in a primary skin cancer.…”

Section: Discussionmentioning

confidence: 97%

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2018

Int J Oncol Res

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terial, samples are strongly S-100 protein reactive. Secretory breast carcinoma is driven by the fusion gene ETV6-NTRK3 that results from a balanced translocation t (12; 15) [6].Fortunately for most diagnosed with SBC, the course is indolent even in the setting of nodal metastasis, which is present in 15-35% cases at presentation [2,3,7]. Although distant metastasis is very rare, local recurrence is described, recurring as far as 16 years after treatment [8]. At present the primary treatment remains surgical. Case ReportA 75-year-old female presented to our clinic with complaint of new onset right nipple pain and swelling for 4 weeks. Family history was significant for breast cancer in a maternal and a paternal first cousin, as well as a maternal aunt who succumbed to her disease at age 50. The initial physical exam revealed a tender, erythematous, enlarged right nipple, but no palpable masses. The initial impression was mastitis, and she was started on azithromycin. A diagnostic mammogram showed asymmetry of the right nipple compared to the left ( Figure 1), however, ultrasound at that time was unremarkable. Her symptoms did not improve with antibiotics.A repeat targeted ultrasound of this area revealed an abnormal right nipple complex (Figure 2). She was then assessed by a breast surgeon, and the exam at that time revealed a firm, tender, erythematous mass of the superior aspect of the right nipple, and a palpable right axillary lymph node. Ultrasound-guided fine needle aspiration biopsy of the axillary node was consistent with metastatic adenocarcinoma. The tumor stained positive AbstractSince first being noted in the literature in 1966, Secretory Breast Carcinoma (SBC) continues to be better defined in terms of its clinical, histologic, and genetic features. However, its unique presentation can elude seasoned practitioners from making a clinical diagnosis. Furthermore, there is neither consensus nor guidelines as to the optimal treatment approach for SBC. We are presenting this case report and literature review to raise awareness about SBC by demonstrating how uniquely this pathology can present itself, to summarize the current literature, and to present our specific approach to this rare cancer.

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“…Juvenile SC usually follows a favorable prognosis. The overall incidence of axillary lymph node infiltration is around 30% in children and adults regardless of gender (16,17). Although lymph node metastases are rarely observed in female patients with SC tumors of ,2 cm in diameter, nodal metastases might occur more frequently in male patients with smaller tumors (18).…”

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confidence: 99%

“…Axillary metastases rarely involve more than three lymph nodes (19). Lymphedema, which is a serious life-long problem, occurs in 6 -30% of the patients treated by axillary dissection (17,20). Sentinel node biopsy procedures have been successfully applied in a few cases of juvenile SC (10,14).…”

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confidence: 99%

A Case of Estrogen Receptor Positive Secretory Carcinoma in a 9-Year-old Girl With ETV6-NTRK3 Fusion Gene

Yorozuya

Takahashi

Kousaka

et al. 2011

Japanese Journal of Clinical Oncology

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The patient was a 9-year-old premenarcheal pediatric female, whose chief complaint was a well-circumscribed palpable right breast mass without nipple discharge. Although the patient had noticed the lump 2 years prior to hospital admission, its size (1.5 Â 1.3 cm) had been stable. There was no family history or previous history of malignancies. Physical examination showed a well-delimited, elastic-firm and movable tumor just beneath the nipple and areolar complex. Regional lymph nodes were not palpable. Ultrasonography and breast computed tomography revealed a subareolar oval-shaped tumor exhibiting homogeneous echogenicity with clear margins. Distant metastases could not be detected using whole-body computed tomographic scans. A fine-needle aspiration cytology specimen showed atypical cells with prominent nucleoli and abundant intracellular secretory material, suggesting the possibility of secretory carcinoma. Histopathological analysis of the core needle biopsy specimen revealed that the tumor was a secretory carcinoma. The patient underwent total mastectomy with sentinel lymph node biopsy. Metastases were not observed in the removed lymph nodes. Estrogen receptor was weakly positive and progesterone receptor was negative. Human epidermal growth factor receptor 2 expression was also negative. In addition, the ETV6 (exon 5) and NTRK3 (exon 13) fusion gene was detected using the reverse transcription -polymerase chain reaction method. This gene is considered specific for secretory carcinoma. Immunohistochemistry revealed weak basal differentiation [cytokeratin 5/6(CK5/6)(þ), vimentin(þ) and epidermal growth factor receptor(þ)]. The patient has received no adjuvant therapy and is currently disease free at 12 months after surgery.

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Secretory breast cancer in childhood and adolescence: Report of a case and review of the literature

Cited by 43 publications

References 18 publications

Secretory breast carcinoma: a clinicopathological and immunophenotypic study of 15 cases with a review of the literature

Secretory breast carcinoma: a clinicopathological and immunophenotypic study of 15 cases with a review of the literature

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A Case of Estrogen Receptor Positive Secretory Carcinoma in a 9-Year-old Girl With ETV6-NTRK3 Fusion Gene

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