The coupling of aryl iodides with alcohols under mild conditions has been explored using self-assembled octanuclear copper clusters as catalysts. Reactions involving tetrahydrofurfuryl alcohol were typically complete in 4-8 h at 110 degrees C using an oil bath or 1-3 h with microwave heating. High yields of alkyl aryl ethers were obtained with catalyst loadings as low as 0.4 mol % cluster.
Phenol ethers Q 0270 Organosoluble Copper Clusters as Precatalysts for Carbon-HeteroelementBond-Forming Reactions: Microwave and Conventional Heating. -The Cu cluster shown in the scheme is found to be an efficient catalyst for the coupling of aryl iodides with tetrahydrofurfuryl alcohol and simple alcohols. The reaction can be carried out using microwave and conventional heating giving similar yields. -(MANBECK, G. F.; LIPMAN, A. J.; STOCKLAND*, R. A. J.; FREIDL, A. L.; HASLER, A. F.; STONE, J. J.; GUZEI, I. A.; J. Org. Chem. 70 (2005) 1, 244-250; Dep. Chem., Bucknell Univ., Lewisburg, PA 17837, USA; Eng.) -Jannicke 22-071
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