A novel nano-material with Cu 2 O nanowires loaded on TiO 2 nanotubes (Cu 2 O/TiO 2 NTs) was prepared in this paper. The new type of catalyst was used to catalyze the C-N and C-O coupling of chlorinated aromatics. The results showed that this catalyst promised the reaction of not only aryl bromide, but also aryl chloride, and most products were synthesized in good to excellent yields. Moreover, the reused experiments confirmed that the catalyst can be recycled five times and present stable yields for reaction.