The crystal structure of a new covalent organic framework, termed COF-320, is determined by single-crystal 3D electron diffraction using the rotation electron diffraction (RED) method for data collection. The COF crystals are prepared by an imine condensation of tetra-(4-anilyl)methane and 4,4'-biphenyldialdehyde in 1,4-dioxane at 120 °C to produce a highly porous 9-fold interwoven diamond net. COF-320 exhibits permanent porosity with a Langmuir surface area of 2400 m(2)/g and a methane total uptake of 15.0 wt % (176 cm(3)/cm(3)) at 25 °C and 80 bar. The successful determination of the structure of COF-320 directly from single-crystal samples is an important advance in the development of COF chemistry.
Three new lanthanide metal–organic frameworks IRHs-(1–3) supported by cyamelurate linkers have been synthesized and structurally characterized. The incorporation of numerous heteroatoms (N and O) into the pore walls and the relatively small microchannels of these porous solids enhance bonding force of the host–guest interactions, thus promoting the adsorption of carbon dioxide (CO2) over methane (CH4). The nonpolar covalent bonds in methane also favor the less uptake due to the hydrophilic walls of these frameworks. Grand canonical Monte Carlo simulations were performed to determine the origin of the adsorption. The density isocontour surfaces show that CO2 is mainly adsorbed on the walls composed of organic linkers and around the metal sites, whereas no specific adsorption site is observed for CH4, which indicates weak interactions between the framework and the adsorbed gas. As expected, the simulations show that CH4 is not observed around the metal center due to the presence of H2O molecules. The excellent selectivity of CO2/CH4 binary mixture was predicted by the ideal adsorbed solution theory (IAST) via correlating pure component adsorption isotherms with the Toth model. At 25 °C and 1 bar, the CO2 and CH4 uptakes for IRH-3 were 2.7 and 0.07 mol/kg, respectively, and the IAST predicated selectivity for CO2/CH4 (1:1) reached 27, which is among the best value for MOF materials.
Background: Although aminoglycosides are often used as treatment for Gram-negative infections, optimal dosing regimens remain unclear, especially in ICU patients. This is due to a large between- and within-subject variability in the aminoglycoside pharmacokinetics in this population. Objective: This review provides comprehensive data on the pharmacokinetics of aminoglycosides in patients hospitalized in the ICU by summarizing all published PopPK models in ICU patients for amikacin, gentamicin, and tobramycin. The objective was to determine the presence of a consensus on the structural model used, significant covariates included, and therapeutic targets considered during dosing regimen simulations. Method: A literature search was conducted in the Medline/PubMed database, using the terms: ‘amikacin’, ’gentamicin’, ’tobramycin’, ‘pharmacokinetic(s)’, ’nonlinear mixed effect’, ’population’, ‘intensive care’, and ‘critically ill’. Results: Nineteen articles were retained where amikacin, gentamicin, and tobramycin pharmacokinetics were described in six, 11, and five models, respectively. A two-compartment model was used to describe amikacin and tobramycin pharmacokinetics, whereas a one-compartment model majorly described gentamicin pharmacokinetics. The most recurrent significant covariates were renal clearance and bodyweight. Across all aminoglycosides, mean interindividual variability in clearance and volume of distribution were 41.6% and 22.0%, respectively. A common consensus for an optimal dosing regimen for each aminoglycoside was not reached. Conclusions: This review showed models developed for amikacin, from 2015 until now, and for gentamicin and tobramycin from the past decades. Despite the growing challenges of external evaluation, the latter should be more considered during model development. Further research including new covariates, additional simulated dosing regimens, and external validation should be considered to better understand aminoglycoside pharmacokinetics in ICU patients.
MOPs and MMOPs were synthesized in water and their crystals exhibit switchable chromic behaviour and reversible solid-state structural transformations.
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