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Background: Bangladesh is an endemic zone for re-emerging dengue viral infection since 2000. For the last few years, dengue viral outbreak occurs in the rainy season mostly in Dhaka city and seldom sporadic case finds beyond the Dhaka city of Bangladesh. But this outbreak expands also outside the Dhaka city of Bangladesh in 2019. Therefore, with scarcity of data regarding this field in the peripheral part of Bangladesh, we have designed this study among dengue infected patients in Jashore, Bangladesh. Objectives: This observational study aims to assess the clinical presentations, laboratory findings especially hematological changes and outcomes of patients with dengue viral infection at Jashore district in dengue outbreak-2019 in Bangladesh. Methodology: This was an observational study, carried out from 25thApril 2019 to 5thSeptember 2019 during dengue outbreak season in Jashore, Bangladesh. Patients were selected from outpatient department and indoor of a local private hospital in Jashore, Bangladesh who had given informed written consent to participate in our study. Result: Total eligible 77 patients were included in this study. Out of which 70 patients (90.9%) were dengue NS1 antigen Positive on Immunochromatography (ICT) and the rest were anti-dengue IgM antibody positive on ICT method. Around 74 (96.1%) patients had fever as the most common feature in dengue infection. Eighty-seven percentages (87%) of patients had history of headache. Other striking complaints were body ache (66.2%), back pain (51.9%), nausea (55.8%), vomiting (31.2%), anorexia (27.3%), arthralgia (29.9%) and retro-orbital pain (26.0%). Sore throat being a common feature in flu-like illness also found in 18.2% cases. Mean total count of whole blood count (WBC) falls on day 5 (5.76 X 109/L) and then gradually increased. Mean platelet count of study patient was normal throughout the course of the disease process. But, in some cases minimum platelets was found 21 X 109/L at the time of presentation and on day 5 and day 6 which was dropped down to 17 X 109/L. Mean Haematocrit (%) was more or less in a steady state throughout the acute phage of the disease. But, in some cases throughout the hospital stay minimum haematocrit was less than 30% and initially in some cases maximum haematocrit was more than 50% among some dengue infected patients. Total 67 (87%) subjects with dengue viral infection required hospital admission and mean hospital stay was 4 days with a standard deviation (SD) was ±2 days. Blood transfusion was required in only one patient. Around 95% patient was recovered and only 4 cases were referred to the higher centre further better management. Regarding complications, we had found diarrhoea in 9(11.7%) and bleeding disorder in 14.3% patients. Conclusion: In our study, the most common clinical presentations were fever, headache, body-ache, back pain, and gastrointestinal upset. The mean hematological started dropping down from 4th day and gradually improved after 7th day. Some patients developed diarrhea, bleeding disorders and hepatitis as complications during their disease process. We observed a good clinical outcome evident by without having severity and death toll among our study participants. There was very seldom requirement of blood and blood product transfusion in our study. J MEDICINE JAN 2021; 22 (1) : 33-40
Initially, Coronavirus disease-2019 (COVID-19) caused by SARS-CoV-2 virus is strikingly thought to be manifested by respiratory illness such as cough, chest tightness, and dysponea. Therefore, we are presenting a confirmed case of COVID-19 who developed acute pancreatitis-a rare manifestation during disease process without any known aggravating factors
Introduction Testicular torsion is a condition requiring immediate attention and the golden time period for its management is 6 hours at which rate of salvageability of the testes is 90 percent (NICE). This decreases considerably with passing time. Imaging has minimal value. Method The electronic data of 36 patients from June 2020 to May 2021 were reviewed and analysed. Majority of patients were between the age of 11–20 i.e., 21. We analysed the mode of admission of these patients, the time between the A&E triage and surgical clerking and A&E triage and induction of anaesthesia. Results Majority (70 percent) patients were admitted through Emergency A&E. The time between the A&E triage and surgical clerking was less than 30 minutes for 10 patients while 11 patients had no proper documentation of time. The time between the A&E triage and the induction of anaesthesia was less than 6 hours in 23 patients, and more than 6 hours for 7 of them. 14 underwent Scrotal Exploration and Bilateral orchidopexy and 13 orchidectomies. Out of 13 orchidectomies, 6 had crossed the golden time period at the time of induction. Out of 10 patients booked for USS testis, 8 underwent Orchidectomy and 6 had crossed the golden hour (6 Hours). Conclusions Early presentation, diagnosis and exploration of testicular torsion improves the salvable rate of testes. 6 patients who underwent USS testis passed the golden timeframe which shows that there is a scope for faster and appropriate management of testicular torsion.
We report a case of a middle aged lady who presented with alteration of consciousness and dysphasia. She was found to have hyponatremia which was corrected rapidly. After initial improvement, she subsequently developed marked deterioration of conscious level with upper motor sign signs in all four limbs. Osmotic demyelination syndrome was diagnosed by MRI. Severe hyponatremia carries a risk of cerebral edema with a significant mortality, but correcting it too rapidly can result in even more disastrous condition-osmotic demyelination syndrome.
Background: Many years have been devoted to preserve fertility, but the effect of cryopreservation on gene functionality in primary, secondary and tertiary follicular stages; is still unclear. The present study was designed to assess the effect of vitrification on the histological structures and expression of follicular cells related genes. Methods: The buffalo ovarian cortical tissues were vitrified in two-steps. The sliced cortical tissues were incubated with VS1 (8.5% DMSO and 8.5% EG) for 10 min and sequentially incubated and stored in liquid nitrogen in VS2 (16.5% DMSO, 16.5% EG and 0.1M Sucrose). Morphological differences were assessed by hematoxylin and eosin staining, which indicated similar structures in both groups. Further, functionality of these follicles were evaluated by the relative gene expression of folliculogenesis-related genes; FOXO3, NLRP5, WNT4, SF1, VEGFA and HAS2. No significant difference was observed between the vitrified groups as compared to control. Moreover, toxicity in follicular cells during vitrification was rectified by MTT assay which also showed no significant difference. Conclusion: Present study can be considered as the key work that helps in filling the gaps regarding the growth of follicles after cryopreservation in buffalo species, as this imparts nonsignificant injury on follicular functionality and development.
Snake bite is an important but often under-recognized public health problem in Bangladesh, with an incidence density one of the highest in the world, which may be 623.4/100,000 person years. The proportion of poisonous snake bites is 10 to 45%, with the reported mortality 0.5 to 22%. Among the 82 species of snakes, 28 are venomous; bites by green pit vipers, cobras and kraits are the most commonly identified ones. High population density, widespread agricultural activities, numerous venomous snake species and lack of functional snake bite control programs favour the high burden of snake bites. Poorer rural populations are the main victims, imposing considerable socioeconomic impact. Treatment of snake bite is largely dominated by traditional snake charmers (Ozha) or 'Kaviraj' offering unscientific practices and healers, causing undue delay and precluding standard medical management. Delayed presentation to the hospital, lack of availability of antivenom and modern management facility are the main causes of death. Antivenoms are entirely dependent on import, are expensive, and are not 'customized' to local needs. Auxiliary intensive care facilities are not widely available; health care personnel often lack necessary expertise. However, the trend is changing. Public awareness is growing, health care personnel are being trained, and a national guideline for snake bite management has been formulated. Further research, introduction of modern diagnostic facilities, local manufacture of antivenom, and above all, integrated approach on the part of Government, policy-makers and international community can change the outlook of snake bite as a neglected tropical condition in Bangladesh.
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