In order to study the neurological manifestations in adult patients suffering from scrub typhus, 323 patients aged over 18 years, admitted with a positive diagnosis, were screened for neurological dysfunction; 37 patients with symptoms and/or signs suggestive of neurological dysfunction were included in the study. Of these, 31 (84%) patients had altered sensorium, four (11%) had cerebellitis, one (2%) patient had acute transverse myelitis and one (2%) had bilateral papilloedema without focal neurological deficit. Of the 31 patients with altered sensorium, 15 (40%) had meningoencephalitis, three (8%) had seizures, two (5%) had cerebral haemorrhages, one (2%) had a presentation likened to neuroleptic malignant syndrome (NMS) and one (2%) had a 6th nerve palsy with inflammation of the right cavernous sinus. Cerebrospinal fluid (CSF) analysis was abnormal in 23 patients (raised lymphocytes in 68%, raised protein in 80%). All patients improved with anti-rickettsial therapy.
Tablet defects can come from any of the unit operation upstream and from the tablet press. The raw materials may be of poor quality or do not meet specification, causing excessive fines that lead to a host of defects. The formulation may be the sour ce of defects if the material do not compress well or the processing step specified within the formulation fail to produce a powder a good flow, compressibility, and ejection properties. The processing and granulation of powder is often the source of defect. Every product behaves differently on a tablet press, even if it's the same product run on a different day. The variation often stems from changes in the properties of the raw materials-active ingredients and excipients-from batch to batch. Naturally, the goal is to minimize these changes. Tablet press operators, however, don't have any control over formulation and granulation. Tablet specifications are tight, and the list of possible defects is long: Variable weight, sticking, picking, capping, lamination, variable hardness, among others. This article focuses on these variations. It pinpoints the possible causes of these defects and offers advice on preventing and fixing the source of the problems.
Rural areas in India may not necessarily have internet connection and what if they need to know about nearest hospitals, fire stations or if a message has to be broadcasted over a large section of this area. This paper tries to solve all of these problems by implementing a pin-code based approach to map these important locations. Now a days, more advanced technologies such as GPS are more useful in solving these problems in real-time but what this paper tries to do is solve them statically where technology can’t take precedence over daily lives. It discusses a smart, fast algorithm with minimum memory overhead to solve these specific issues. Lack of data sets are a concern in this approach but to automate this we have used Image Processing to automatically detect boundaries of pin-codes on various sub-regions to form a universal Graph which can then be subjected to various algorithms like A*, DFS, BFS, Dijkstra which are local to each type of problem. This leaves scope for further research on developing models that can read images of maps more efficiently to create more accurate data sets which are accurate enough and void of longitudinal and latitudinal details.
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