Phyllodes tumours are rare breast tumours, accounting for 0.3-1% of all breast cancers and 2.5% of fibroepithelial tumours. They occur in younger age women in Asian countries. These can be classified into benign, borderline and malignant based on stromal hypercellularity, mitotic figures, cellular pleomorphism, stromal overgrowth and nature of the tumour borders. Synchronous coexistence of phyllodes tumour and invasive breast carcinoma in the contralateral breast is very rare, and probably the second one reported in the literature. Hereby, we report a case of a middle-aged woman presenting with a lump in the bilateral breast, diagnosed to have benign phyllodes of one breast and Invasive carcinoma of the contralateral breast.
Pancreatic heterotopia is a rare, unusual finding where pancreatic tissues are found out of the normal anatomical location. Various studies have documented an incidence of 0.5 to 13% in autopsy. The reports on pancreatic heterotopia presence is rare, with an incidence estimated to be around 0.2% of all upper gastrointestinal surgeries. The heterotopic pancreas occurs frequnetly in the stomach, duodenum and proximal jejunum. Remote cases of pancreatic heterotopia in Meckel's diverticulum is a rare finding. These heterotopias are often clinically silent and are an incidental findings upon pathological examination or autopsy.
Background Neonatal sepsis is the most common cause of neonatal mortality and morbidity. As neonatal sepsis presents with subtle symptoms and signs, decision to start empirical antibiotics is most often based on risk profile. Hematological parameters and C-reactive protein (CRP) are routinely done as a part of sepsis screening, but isolation of microorganism on blood culture is the gold standard for diagnosis of sepsis.
Methodology One-hundred neonates with suspected sepsis were studied and their hematological parameters, hematological scoring system (HSS), and CRP were correlated to blood culture.
Results Among the study population, immature to total neutrophil count (I:T) ratio had the best sensitivity (94.1%) and negative predictive value (83.3%), followed by HSS with a sensitivity of 64.7% and negative predictive value of 68.4%, whereas CRP was more specific (75.9%).
Conclusion HSS and CRP are good predictors of diagnosis of neonatal sepsis. I:T ratio had the best sensitivity and negative predictive value.
Follicular carcinoma of the thyroid accounts for 5-15% of all the primary cancers of thyroid. Follicular carcinoma clinically manifests as a painless neck mass and rarely presents with metastatic bony lesion, the most common site being the spine. Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) constitute 10-20% of all thyroid cancers. The histopathological diagnosis of thyroid follicular carcinoma mandates demonstration of either capsular/vascular invasion. Differentiating between follicular carcinoma and NIFTP is challenging based on histology. Hence extensive sampling of the pathological specimen is required to differentiate the same. Herein we report a case of an elderly woman presented with a pathological fracture of the femur due to metastasis from follicular carcinoma of the thyroid with an incidental NIFTP of the left lobe of the thyroid.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.