Aim:To evaluate the antiamnesic and antidepressant effect of Foeniculum vulgare whole crushed seeds. Study Design: Laboratory based randomized control study. Place and Duration of Study: Methodology: Thirty swiss albino mice and wistar rats were divided equally in three groups. Control group was fed on standard rodent diet, group 2 was fed on 2% Foeniculum vulgare diet and group 3 was given 4% Foeniculum vulgare diet. Antidepressant activity was assessed using forced swimming test. Memory enhancement effect was evaluated by stationary rod test, passive avoidance test and water maze test. Abbas et al.; JAMMR, 32(1): 131-138, 2020; Article no.JAMMR.54564 132 Results: Increased duration of struggling time was noted in both group 2 and group 3 as compared to control in forced swimming test. Decrease in time to reach platform in both water maze and stationary rod test was recorded in both the study group (group 2 & 3). Increase in step through latency was also seen in group 2 and group 3 as compared to control group. Conclusion: The results showed the memory enhancing and antidepressant actions of Foeniculum. Original Research Article
Aims: Coagulation profile shows the clotting ability of blood. Biochemical tests indicate health status of vital organs such as liver, heart and kidneys. Herbal products are being assessed for their role in affecting these parameters. We evaluated role of Foeniculum vulgare incorporated diet on coagulation profile and some important biochemical parameters. Study Design: Laboratory centred randomized controlled trial. Place and Duration of Study: Pharmacology Department of University of Karachi, Karachi between June 2018 and September 2018. Methodology: After selecting 30 healthy rabbits of either sex, we placed them in three groups; Control, 2% Foeniculum vulgare and 4% Foeniculum vulgare group. Control group was given standard diet whereas; 2% and 4% Foeniculum vulgare groups were maintained on standard diet containing 2% and 4% Foeniculum vulgare crushed seeds. Coagulation profile and some biochemical parameters were done after interval of a month, for two months. Results: Platelet count and fibrinogen increased while activated partial thromboplastin time (APTT) levels decreased in both the study groups animals as compared to control, while blood urea nitrogen (BUN), creatinine phosphokinase (CPK) and lactate dehydrogenase (LDH) elevation was noted both Foeniculum vulgare groups but within normal range. Conclusion: Foeniculum vulgare may have some role in affecting coagulation and biochemical profile These parameters, however, need clinical trial to validate reliability.
Aims: Alzheimer disease and epilepsy are two of the central nervous system (CNS) disorders that not only affect the quality of life of patients but also of family members and caretakers. Remedies for these illnesses are available in allopathic medicines but not without side effects. Herbal products are being investigated for these ailments. Protective role of Foeniculum vulgare Mill. was assessed in this study. Study Design: Laboratory based randomized controlled trial. Place and Duration of Study: Conducted in Pharmacology Department of University of Karachi, between March 2018 and April 2018. Methodology: Mice and rats were divided in three groups, control, 2% and 4% F. vulgare groups, each containing 10 rodents. Control group was fed standard rodent diet, whereas, study groups were given 2% and 4% F. vulgare seeds (crushed) incorporated in standard rodent diet. Epilepsy model was made for mice and Alzheimer disease study was done using rats and passive avoidance test. Results: Lower incidence of seizures and mortality in both study groups as compared to control in epilepsy model and memory retaining effect in both treated groups in Alzheimer disease model was recorded with statistical significance. Conclusion: Clinical studies should be conducted to validate the protective role of this herb in these disorders.
Aims: Anemia is prime health issue of the population in developing region of world mostly due to dietary deficiencies and poor sanitation. Supplementary medicines as well as iron rich foods are utilized to combat this problem. Herbal products also have value in such diets. We evaluated role of Foeniculum vulgare incorporated diet on hemoglobin concentration and related indices. Study Design: laboratory centred randomized controlled trial. Place and Duration of Study: Pharmacology Department of University of Karachi, Karachi between June 2018 and September 2018. Methodology: After selecting 30 healthy rabbits of either sex, we placed them in three groups; Control, 2% Foeniculum vulgare and 4% Foeniculum vulgare group. Control group, 2% and 4% Foeniculum vulgare groups were maintained on standard rodent diet, standard rodent diet containing 2% and 4% Foeniculum vulgare crushed seeds, respectively. Complete blood count of all rabbits was done twice after interval of a month. Results: In comparison to control group, hemoglobin levels increased in both the study groups, while leucocyte count (WBC) increase was noted only in 4% Foeniculum vulgare group. Conclusion: Foeniculum vulgare may have some role in maintenance of hemoglobin levels if not improving it.
The extent to which music research has penetrated the medical science literature relative to other forms of research remains unclear. We sought to explore temporal changes in the number of music related publications relative to all medical literature as well as prespecified research subdomains of drug therapy, alternative therapy, and neuroscience between 1970 and 2019. We conducted a bibliometric review in which we quantified the number of annual publications between 1970 and 2019 using MEDLINE (PUBMED) search engine and mesh terms of “Music”; “Drug therapy”; “Alternative Medicine”; “Neuroscience”. The number of publications were quantified relative to all publications within their corresponding years. We also examined the types of journals, geographical location of publication (Based on corresponding author), and journal impact factors. To ensure appropriate content, we conducted a hand review of a random 400 abstracts to ensure they met appropriate criteria for music-medical research. We used log-linear regression, to test differences in growth rates. We determined that the relative growth in the number of music publications accelerated at a rate higher than all medical related publications or those confined to drug therapy. The proliferation of music research was attributable to higher rates of neuroscience, alternative therapy, and music therapy research. In conclusion, the temporal growth in number of music research publications relative to other comparators over the past 50 years underscores the importance, relevance, and maturation of music as an evolving discipline of contemporary medical science.
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