The acute mortality (14-day LC50) to the guppy (Poecilia reticulata) of reactive organic halides was determined. These compounds were significantly more toxic than the non-reactive organic chemicals with unspecific toxicity. The 14-day LC50 of 15 compounds was correlated with hydrophobicity (P oct ) and a chemical reactivity parameter (reaction rate constants with 4-nitrobenzylpyridine). The quality of the QSAR with chemical reactivity as parameter was much better than of a QSAR with P oct

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Quantitative structure-activity relationships (QSARs) were calculated for the acute lethal toxicities (1Cday LC,,) to the guppy (Poecilia reticulata) of anilines, with several hydrophobicity characteristics and the Hammett (T constant as parameters. Calculated and experimental Pm values and II constants were used as hydrophobicity characteristics. Introduction of Hammett constants improved the quality of the QSARs. Together with the QSAR studies the toxicities of mixtures of the anilines were determined. The toxicities of three mixtures did not deviate from concentration addition.