Quantitative structure-activity relationships and mixture toxicity of organic chemicals in Photobacterium phosphoreum: The microtox test

Assessment of the potential toxicity of herbicides and their degradation products to nontarget cells using two microorganisms, the bacteria Vibrio fischeri and the ciliate Tetrahymena pyriformis

“…No correlation was revealed using the Microtox test, which seems a less powerful reference test in terms of predicting the toxicity of these molecules. This is in agreement with the results of Hermens et al (1985) who reported that the Microtox test was not sensitive to very high lipophilic compounds. The absence of a significant correlation in the case of nonspecific esterase activities test is not in agreement with the results obtained by Bogaerts et al (2001) for other organic molecules having insecticidal, herbicidal, and fungicidal properties.…”

Comparison of Acute Toxicity and Genotoxic Concentrations of Single Compounds and Waste Elutriates Using the Microtox/Mutatox Test System

“…Introduction of molar refractivity (MR)-a function of the index of refraction, density, and molecular weight-and molar volume (MW/d) improved the quality of the relationships. The influences of MR or MW/d could be related with an interaction of the tested chemicals to the enzyme luciferase or the reduced Flavin mononucleotide (FMNH 2 )-donating system (Hermens, 1985). The EC 50 s of 55 chlorinated aromatic compounds were correlated with log P OW and the hydrophilic effect parameter (V H ) by Kaiser et al (1985).…”

The Acute Toxicity of α-Branched Phenylsulfonyl Acetates in Photobacterium phosphoreum Test

“…QSARs are developed for the Microtox data of di!erent sets of chemicals. Most of these QSARs are based on the octanol/water partition coe$cient (Hermens et al, 1985;Zhao et al, 1993). Additionally, LSER parameters (Kamlet et al, 1986) are used to model nonspeci"c reactive toxicity.…”