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The association of a variant N with a 'new' antigenic type of the Miltenberger sub-system, the first example of which was described recently, has been found in three further non-related persons. The 'new' Miltenberger type, Cell Class V, is defined by the reactions Vw-(Mi(a-) Mur-Hil+, for which the 'shortland' symbol Mi.V is proposed. The N variant is characterized by fair to normal reactions with rabbit and Yicia graminea, but weak or negative reactions with most human anti-N reagents. The responsible gene complex, N s M i ' V , also gives rise to a variant s antigen, which reacts exaggeratedly with most anti-s sera by the antiglobulin method, and not at all with one anti-s in saline.The first example of the gene complex M s M i ' V is described, which gives rise to variant M and s, whose reactivity is quite analogous to the variant N and s observed in the other cases. The findings are discussed, in particular with regard to their bearing on the interrelationship between so-called satellites and the main antigens of the MNSs system. The Miltenberger 'sub-system' was shown by CLEGHORN [l] to consist of 4 phenotypes, called Cell Classes, which are distinguishable from each other by their reactions with 4 types of antisera. To these 4 cell classes, a fifth was added recently by CROSSLAND et al. [3]. In the present paper, 4 more examples of this 'new' class are reported. We propose using for it the shorthand symbol 'Mi -V' instead of the cumbersome 'Miltenberger Cell Class V'. Accordingly, the gene complex responsible for this phenotype in 3 of our 4 examples will be written N s M i * V ; like in the original example [3], it gives rise to a depressed N antigen. The gene complex involved in our fourth example is M s M i . V , and it is associated with a depressed M antigen, which is readily distinguished from other kinds of M 'variants' encountered so far.

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