Currently CAD-CAM systems are rapidly gaining importance in dental practice as some of their products aim to combine aesthetics with strength and are free of metals. This study reports on the crown adaptation, marginal fit and clinical behaviour of 300 all-ceramic full coverage restorations (Procera, Gothenburg, Sweden) placed in one clinical centre and followed up to 5 years. The marginal fit and coping adaptation before and after luting was determined by direct measurement as well as after sectioning in a laboratory study. Three hundred all-ceram restorations were installed in 165 patients between 1994 and 1998. Before the end of 2000, patients were recalled to assess their restorations, using the California Dental Association quality evaluation index, their own appreciation, as well as the reaction towards the periodontium. The in vitro data revealed a mean marginal adaptation of 30 microm, before and after luting of the Al(2)0(3)-coping onto the tooth. However, at the deepest part of the chamfer, the distance increased to 135 microm. In the clinical study only one restoration fractured, while in 6% small porcelain infractions occurred. After polishing the latter, no persistent patient complaints remained. At the last recall visit 1.8% of the margins were rated unacceptable. Dentists rated 72 and 78% of the restorations excellent for surface, colour and anatomic form respectively. Eighty-seven per cent of the patients rated their restorations more than 7/10 on an ordered analogue scale for aesthetics as well as for function.

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Although theoretical models predict uptake of inhaled anesthetics during closed-circuit anesthesia (CCA), clinical data for most anesthetics are conflicting or non-existent. In addition, the effects of patient characteristics and mode of ventilation on anesthetic uptake are unclear. Forty-one ASA physical status I or II adult patients undergoing a variety of 1-1.5 h surgical procedures were randomly allocated to receive CCA with desflurane or isoflurane with ventilation being either spontaneous or controlled. An end-expired anesthetic concentration of 1.3 minimum alveolar anesthetic concentration (MAC) was maintained by continuous injection of the liquid anesthetic into the circuit using a syringe pump. After an initial 4-min wash-in period, uptake during the first hour of CCA was nearly constant. Uptake was the same whether ventilation was spontaneous or controlled. Patient characteristics (age, height, weight, weight3/4, and body surface area) were comparable between groups and did not correlate with uptake. The virtually constant uptake after wash-in of desflurane and isoflurane contrasts with the square root of time model of Lowe and Ernst. These findings may greatly simplify CCA.

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Two hundred and forty-one neonates who had been delivered vaginally were selected randomly. The control group consisted of infants delivered without anaesthesia. In the study groups either extradural (mepivacaine, lignocaine or bupivacaine), spinal or general anaesthesia was administered. Each of the six groups was divided into breast- and bottle-fed subgroups. The results showed no significant difference in weight changes among the various groups. The bottle-fed subgroup showed less weight loss than the breast-fed subgroup (P less than 0.05). There was no interaction between method of feeding and type of anaesthesia.