Bupivacaine, 0.125 Per Cent, in Obstetric Epidural Analgesia

Bleyaert, Achiel L.; Soetens, M.; Vaes, L.; Steenberge, A L Van; Donck, A. Van Der

doi:10.1097/00132586-198012000-00049

Cited by 1 publication

(1 citation statement)

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“…Also contributing to selective blockade is the fact that myelinated nerves require blockade of at least three nodes of Ranvier to halt impulse conduction and the increased internodal distance in larger nerves makes these nerves more resistant to blockade (Fink, 1989). Not only fibre-type but also specific drugs can contribute to differential blockade with bupivacaine (0.125%) reported to have more sensory than motor blockade (Bleyaert, Soetens, Vaes, Steenberge, & Donck, 1979). Ropivacaine and levobupivacaine (Camorcia, Capogna, Berritta, & Columb, 2007) and liposome-encapsulated bupivacaine (Joshi, Patou, & Kharitonov, 2015) cause less motor blockade than regular bupivacaine.…”

Section: Local Anaesthetic Drug Propertiesmentioning

confidence: 99%

Local and regional anaesthesia in dogs and cats: Overview of concepts and drugs (Part 1)

Grubb

Lobprise

2020

Veterinary Medicine & Sci

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Pain management in veterinary patients is a crucial component of appropriate patient care. Multimodal analgesia that includes both systemically and locally/regionally administered drugs is generally the most effective approach to providing pain relief. Local anaesthetic drugs used in local and regional blockade are unique in that they can completely block the transmission of pain (in conscious patients) or nociceptive (in anaesthetized patients) signals, thereby providing profound analgesia. In addition, local and regional administration of drugs, when compared with systemic bolus administration, generally results in a lower incidence of dose‐related adverse effects. Due to the potential to provide profound analgesia and the high safety margin (when used correctly) of this drug class, local anaesthetics are recommended as part of the analgesic protocol in the majority of patients undergoing surgical procedures or suffering traumatic injuries. This manuscript, Part 1 of a two‐part instalment, emphasizes the importance of using local and regional anaesthesia as a component of multimodal analgesia, provides a review of the basic pharmacokinetics/pharmacodynamics of local anaesthetic drugs in general, lists information on commonly used local anaesthetic drugs for local and regional blockade in dogs and cats, and briefly introduces the novel liposome‐encapsulated bupivacaine (NOCITA®). Part 2 is a review of local and regional anaesthetic techniques used in dogs and cats (Grubb & Lobprise, 2020).

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Section: Local Anaesthetic Drug Propertiesmentioning

confidence: 99%