Objective In red blood cell (RBC) isoimmunized pregnancies fetal anemia is associated with a hyperdynamic circulation. The aim of the present study was to examine further the possible value of fetal middle cerebral artery peak systolic velocity (MCA-PSV)

ABSTRACT

the use of multiple endocrine parameters showed a high prevalence of biochemical hyperandrogenism in patients with PCOS. Two thirds of the patients had adrenal hyperandrogenism, and estradiol and insulin did not influence adrenal secretion.

Hypoadiponectinaemia in NAFLD was associated with dietary sucrose and fatty food intake, emphasising the important role of diet in the occurrence of this disease.

OBJETIVO: Avaliar o comprimento do colo uterino pela ultrassonografia transvaginal em uma população de gestantes normais e construir uma curva de normalidade no período de 20 a 34 semanas de gestação. MATERIAIS E MÉTODOS: Estudo de corte transversal, incluindo 145 gestantes normais, com feto único, vivo, sem enfermidades, entre 20 e 34 semanas de gravidez, examinadas nos serviços de ultrassonografia do Hospital Universitário Júlio Müller e de uma clínica privada. As gestantes foram submetidas a ultrassonografia endovaginal, com registro do comprimento cervical. Critérios de exclusão foram: parto prematuro, rotura prematura pré-termo das membranas, placenta prévia, uso de fármacos tocolíticos e/ou progesterona, cerclagem ou qualquer intervenção cirúrgica prévia no colo. A associação entre o comprimento do colo uterino e a idade gestacional foi examinada por regressão linear. RESULTADOS: O comprimento cervical diminuiu progressivamente em 0,8 mm a cada semana, à medida que a idade gestacional progrediu (r = -0,351; p < 0,001). As mulheres que tiveram afunilamento cervical apresentaram colo mais curto que as demais (p = 0,001). A interpolação dos percentis 5, 50 e 95 provê gráfico passível de ser utilizado como referência. CONCLUSÃO: O comprimento médio cervical em gestantes normais diminui 0,8 mm por semana, entre a 20ª e a 34ª semanas de gestação.

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Poster abstractswhich is a local tertiary referral center. Gestational age at referral was defined as time of diagnosis. The cases in which the malformation was already known for more than one week and fetuses with further malformations were excluded. The number of fetuses, mean gestational age at diagnosis, the rate of fetuses with diagnosis before 17 weeks of gestation (wks) and 25 wks and reason for referral were compared between three groups: 1994-1996 (group I), 1997-1999 (group II) und 2000-2003. Results: In 77 fetuses between 14 and 36 wks a spina bifida was detected. The number (n) and mean gestational age at diagnosis was n = 12 at 23.0 + 6.5 wks in group I, in group II n = 24 at 23.8 + 6.3 wks and in group III n = 41 at 22.2 + 5.9 wks. The rate of diagnosis before 17 wks was 0%, 12.5% and 17.0% and before 25 wks 66.0%, 62.5% and 73.2%, respectively. The reason for referral was the suspicion of a fetal malformation in 52.0% in group II and 70.7% in group III. Conclusions: Our results show a slow decrease in gestational age of the prenatal diagnosis of spina bifida and an increasing rate of fetuses referred for malformations to the tertiary centre during a decade. However, in a quarter of all affected fetuses the diagnosis is still made after 24 weeks of gestation. If the benefit of fetal surgery to prevent secondary damage will be proved, an early diagnosis of spina bifida will be important for these individuals. Cleido-cranial dysplasia (CCD) is characterized by a triad of calvarial dysostosis, hypoplasia or absence of clavicles, and supernumerary permanent teeth. The delayed calvarial ossification necessitates a planned Cesarean section in order to prevent a possible severe brain damage during birth. Therefore, early recognition of CCD is of major clinical importance. In the present case report, the patient was a 30-year-old gravida 2 para 1 with RUNX2-negative CCD. Family history comprised three generations of clinically diagnosed CCD; including the father of the patient and her first child born in 2000. An ultrasound examination was performed using a GE Voluson 730 Expert scanner at week 13 + 6. The severely delayed ossification of the vertebral spine was easily seen as echo poor, nearly black vertebral bodies, both on longitudinal as well as on transverse sections. In the calvaria, only the frontal bone showed signs of calcification, confirming severe delay in calvarial ossification. The clavicles were barely seen, lacking the typical S-shape. Except for short femurs, all other anatomic structures were normal for gestational age. Serial ultrasound examinations during pregnancy confirmed the diagnosis, but as ossification progressed the above mentioned manifestations became less distinct. A Cesarean section was performed in week 38. The infant had the same clinical signs of CCD as his affected family members. In conclusion, this case demonstrates that early ultrasound around thirteen weeks should be performed in pregnancies at risk of CCD since delayed mineralisation of the vertebral spine is an ea...

Poster abstracts Conclusion: A subfreezing 22 gauge spinal needle does not decrease pain associated with second trimester genetic amniocentesis.