Hypoadiponectinaemia in nonalcoholic fatty liver disease obese women is associated with infrequent intake of dietary sucrose and fatty foods

Magalhães, Graciane Catarina Batista; Feitoza, Francilene; Moreira, Santos; Carmo, A. V.; Souto, Francisco José Dutra; Reis, Sílvia R.L.; Martins, Maria Salete Ferreira; Silva, M. H. G. Gomes da

doi:10.1111/jhn.12110

Cited by 8 publications

(7 citation statements)

References 56 publications

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“…There is evidence that leptin levels are associated with liver disease (30)(31)(32) ; it is possible that the present study did not show significant correlations because all of the studied individuals presented obesity and thus tended to present high levels. The role of resistin in the development and progression of NAFLD is not so well established and the previous available evidence showed mixed results, with some authors reporting a significant association with NAFLD (33)(34)(35) , and others demonstrating no differences (36)(37)(38) . D'Incao et al have observed that leptin levels were inversely correlated with the degree of steatosis, and also that resistin levels were inversely correlated with fibrosis stages (18) .…”

Section: Discussionmentioning

confidence: 99%

Correlation Between Nonalcoholic Fatty Liver Disease Features and Levels of Adipokines and Inflammatory Cytokines Among Morbidly Obese Individuals

Baltieri

Chaim

et al. 2018

Arq. Gastroenterol.

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BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is the commonest hepatopathy worldwide. OBJECTIVE: To investigate the correlations between NAFLD histopathological features and the levels of adipokines (adiponectin, leptin, and resistin) and circulating inflammatory markers (interleukin-6 [IL-6], interleukin-8 [IL-8], tumor necrosis factor alpha [TNF-α], and C-reactive protein [CRP]). METHODS: This is an exploratory cross-sectional study, which enrolled 19 women with obesity who underwent bariatric surgery. Biochemical characteristics evaluated included the levels of adiponectin, leptin, resistin, IL-6, IL-8, TNF-α, and CRP. NAFLD was assessed through histological examination of liver biopsies carried out during the surgical procedures. RESULTS: The mean age of the study group was 37.3±8.2 years old; mean BMI was 36.2±2.5 kg/m2. Among individuals with liver fibrosis, the levels of IL-8 were significantly higher (24.4 ± 9.7 versus 12.7 ± 6.6; P=0.016726). The intensity of fibrosis presented a significant negative correlation with the levels of adiponectin (R= -0.49379; P=0.03166); i.e. the higher the levels of adiponectin, the lower the intensity of fibrosis. The intensity of steatohepatitis presented a significant negative correlation with the levels of adiponectin (R= -0.562321; P=0.01221); this means that the higher the levels of adiponectin, the lower the intensity of steatohepatitis. CONCLUSION: Adiponectin levels were inversely correlated with the severity of fibrosis and steatohepatitis, whereas IL-8 levels were higher in individuals with liver fibrosis among individuals with obesity and NAFLD undergoing bariatric surgery. The use of these markers to assess NAFLD may bring significant information within similar populations.

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Section: Discussionmentioning

confidence: 99%

Correlation Between Nonalcoholic Fatty Liver Disease Features and Levels of Adipokines and Inflammatory Cytokines Among Morbidly Obese Individuals

Baltieri

Chaim

et al. 2018

Arq. Gastroenterol.

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“…However, Magalhaes et al . 36 investigated the serum levels of resistin in obese NAFLD patients and controls, but they found that the serum levels of resistin were negatively associated with the risk of NAFLD; that is, the serum resistin levels were low in NAFLD patients compared to controls. Except for the above reports, other research investigations also provided findings that precluded making a definitive conclusion.…”

Section: Discussionmentioning

confidence: 99%

Serum Resistin Levels in Adult Patients with Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-analysis

Han¹,

Chen²,

Liu³

et al. 2021

Journal of Clinical and Translational Hepatology

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“…Magalhaes et al [114] 2014 Cross-sectional study 60 obese women with nonalcoholic fatty liver disease or apparently healthy, aged >20 y Diet rich in sucrose was significantly related to low AD concentrations (<0.35 µg/mL) in healthy women (p = 0.054) and in women with NAFLD (p = 0.045). Diet rich in sweets (p = 0.046) and sweetened beverages (p = 0.054) was significantly correlated with low AD concentrations in healthy women (<0.35 µg/mL).…”

Section: Monosaccharides and Disaccharidesmentioning

confidence: 99%

“…They reported that a diet rich in fructose was associated with significantly lower adiponectin concentrations. Besides, Magalhaes et al [ 114 ] demonstrated that adiponectin was also influenced by the consumption of sucrose which is a disaccharide. Participants whose diets were rich in sucrose were characterized by significantly reduced adiponectin concentrations (<0.35 μg/mL).…”

Section: Diet-related Factors With a Negative Influence On Adiponectin Concentrationsmentioning

confidence: 99%

The Influence of Nutrition on Adiponectin—A Narrative Review

2021

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The adipose tissue is an active endocrine organ which synthesizes and secretes a variety of adipokines, including adiponectin with its anti-inflammatory properties. Its expression is influenced by numerous factors such as age, sex, body weight and adipose tissue content. However, dietary factors, i.e., diet structure and the percentage of individual nutrients and products, are very important modulators. Beneficial dietary habits are the Mediterranean diet, DASH diet, diet based on plant products and diet with reduced energy value. Moreover, the share of individual products and nutrients which increase the concentration of adiponectin is worth noting. This group may include monounsaturated fatty acids, polyunsaturated omega-3 fatty acids, dietary fiber, polyphenols, alcohol and milk products. Conversely, dietary ingredients which have a negative effect on the concentration of adiponectin are typical components of the Western diet: saturated fatty acids, trans fatty acids, monosaccharides and disaccharides, and red meat. Furthermore, a diet characterized by a high glycemic index such as a high-carbohydrate low-fat diet also seems to be unfavorable. Due to the fact that available knowledge should be systematized, this study aimed to summarize the most recent research on the influence of dietary factors on the concentration of adiponectin.

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Hypoadiponectinaemia in nonalcoholic fatty liver disease obese women is associated with infrequent intake of dietary sucrose and fatty foods

Abstract: Hypoadiponectinaemia in NAFLD was associated with dietary sucrose and fatty food intake, emphasising the important role of diet in the occurrence of this disease.

Cited by 8 publications

References 56 publications

Correlation Between Nonalcoholic Fatty Liver Disease Features and Levels of Adipokines and Inflammatory Cytokines Among Morbidly Obese Individuals

Correlation Between Nonalcoholic Fatty Liver Disease Features and Levels of Adipokines and Inflammatory Cytokines Among Morbidly Obese Individuals

Serum Resistin Levels in Adult Patients with Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-analysis

The Influence of Nutrition on Adiponectin—A Narrative Review

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