Hyperlipaemia persisted for more than 12 months in rats treated with cobalt chloride, 9 of 20 treated rats and 1 control rat died within the first year, and 8 of the surviving animals developed fibrosarcomas--in 4 of these the tumour was far removed from the injection sites. The results are discussed with reference to the use of cobalt chloride treatment for anaemia in patients with chronic renal failure.
Intestinal insulin releasing polypeptide (IRP) has been shown to potentiate the release of insulin in response to glucose both in vitro and in v2vo in the rat. Adrenaline reduced the insulin secretory response to the intravenous infusion (I.V.) of glucose and to the infusion of glucose with IRP given either as a rapid injection or as constant infusion.
A greatly elevated and sustained insulinemic response was evoked in cats by the intravenous infusion of a solution of IRP in glucose compared with that produced by glucose alone. Larger doses of IRP produced correspondingly greater increases in insulin release.
IRP enhanced glucose disposal up to a finite limit despite higher plasma insulin levels suggesting that there is a maximum rate of glucose disposal under conditions of intense insulin stimulation.
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