1974
DOI: 10.1007/bf01221641
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The effect of adrenaline on insulin releasing polypeptide (IRP) mediated insulin releasein vivo in the rat

Abstract: Intestinal insulin releasing polypeptide (IRP) has been shown to potentiate the release of insulin in response to glucose both in vitro and in v2vo in the rat. Adrenaline reduced the insulin secretory response to the intravenous infusion (I.V.) of glucose and to the infusion of glucose with IRP given either as a rapid injection or as constant infusion.

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Cited by 2 publications
(4 citation statements)
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“…The nature of the acid did not significantly affect the desorption of the reagent. At equal concentrations of HNO 3 and HCl the desorption of the reagent was comparable. Presence only one sulfonate group in the NNS molecule causes weaker fixation of NNS on the surface of SiO 2 -PHMG than NRS, having two sulfonate groups [42].…”
Section: Resultsmentioning
confidence: 90%
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“…The nature of the acid did not significantly affect the desorption of the reagent. At equal concentrations of HNO 3 and HCl the desorption of the reagent was comparable. Presence only one sulfonate group in the NNS molecule causes weaker fixation of NNS on the surface of SiO 2 -PHMG than NRS, having two sulfonate groups [42].…”
Section: Resultsmentioning
confidence: 90%
“…Stability of fixation of NNS on the surface of SiO 2 -PHMG was studied by treating of the sorbent with surface concentration of NNS 14 µmol g -1 with solutions of NaCl, HCl and HNO 3 . The results are represented in (Table 1).…”
Section: Resultsmentioning
confidence: 99%
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“…Unlike crude extracts of intestinal mucosa, IRP regularly stimulated insulin release both in the rat (Turner and Marks, 1972) and the baboon (Turner et al, 1974a), but only in the presence of at least minimal hyperglycaemia. The insulinotropic effects ofan IRP-containing infusion were maintained for as long as the infusions continued and were markedly attenuated by simultaneous adrenaline administration (Shabaan et al, 1974). Shortly after his description of IRP, Turner obtained small amounts of each of three newly isolated intestinal hormones from their respective discoverers and tried them out in his bioassay system.…”
Section: Glucagonmentioning
confidence: 99%