Fibrosarcomas induced by cobalt chloride (CoCl₂) in rats

Abstract

Hyperlipaemia persisted for more than 12 months in rats treated with cobalt chloride, 9 of 20 treated rats and 1 control rat died within the first year, and 8 of the surviving animals developed fibrosarcomas--in 4 of these the tumour was far removed from the injection sites. The results are discussed with reference to the use of cobalt chloride treatment for anaemia in patients with chronic renal failure.

Toxicology‐based cancer causation analysis of CoCr‐containing hip implants: a quantitative assessment of genotoxicity and tumorigenicity studies

“…Shabaan et al . () reported that 10 subcutaneous injections of 9.6 mg kg −1 per day of Co administered over 19 days in male Wistar rats resulted in systemic fibrosarcomas in 36% of the treated animals at 12 months. However, the authors did not report systemic tumor rates in the control groups.…”

Cobalt in periprosthetic soft tissue: Observations in 6 revision cases

“…Because Co powder and CoCI2 have been reported to induce soft-tissue sarcomas following parenteral administration to rats (Heath 1956, Shabaan et al 1977. it is arguable that cobalt deposited in patients' tissues could pose a carcinogenic hazard.…”

Cobalt und Cobaltverbindungen (in Form atembarer Stäube/Aerosole) [MAK Value Documentation in German language, 2001]

“…Cobalt(II)chlorid erzeugte nach subkutaner Injektion bei Ratten in hohen toxischen Dosen lokale Sarkome (Shabaan et al 1977 Heath 1954, 1956Heath 1954, 1956 Cobalt ( (Alexandersson 1979a(Alexandersson , 1979b. Akute, reversible Effekte (Reizung der Atemwege, verminderte forcierte Vitalkapazität) wurden bei gesunden Personen beobachtet, die akut gegenüber 0,038 mg Co/m 3 exponiert waren (Kusaka et al 1986a).…”