Cobalt in periprosthetic soft tissue: Observations in 6 revision cases

Cg, Lewis; Rm, Belniak; Hopfer, Sidney M.; Fw, Sunderman

doi:10.3109/17453679108996641

Cited by 18 publications

(3 citation statements)

References 30 publications

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“…Metal release to the periprosthetic tissues is well known. 2,4,22,[43][44][45][46] Disseminated metal particles have been shown to accumulate in regional lymph nodes causing sinus histiocytosis, 47 necrosis 48 and cytokine production. 49 Furthermore, accumulation in distant organs 30,48,50,51 has also been clearly demonstrated.…”

Section: Discussionmentioning

confidence: 99%

Elevated Serum Cobalt With Metal-on-Metal Articulating Surfaces

Brodner¹,

Bitzan²,

Meisinger³

et al. 1997

The Journal of Bone and Joint Surgery. British volume

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We determined serum cobalt levels in 55 patients by atomic absorption spectrophotometry before and after implantation of uncemented total hip arthroplasties. In a randomised, prospective trial 27 wrought Co-28Cr-6Mo-0.2C metal-on-metal articulations were compared with 28 ceramic-on-polyethylene hips which did not contain cobalt. Other sources of iatrogenic cobalt loading were excluded. The metal-on-metal group produced detectable serum cobalt levels (median 1.1 g/l after one year) which were significantly different (p < 0.0001) from those of the ceramic-on-polyethylene control group (median below detection limit of 0.3 g/l after one year). Our findings indicate that metal-on-metal bearings generate some systemic release of cobalt.

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Section: Discussionmentioning

confidence: 99%

Elevated Serum Cobalt With Metal-on-Metal Articulating Surfaces

Brodner¹,

Bitzan²,

Meisinger³

et al. 1997

The Journal of Bone and Joint Surgery. British volume

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“… 2 During the above procedures, the surface of material first interacts with the body environment and plays a more important role than the bulk material. 3 In addition, the delivery of antimitotic or antithrombotic particulate pharmaceuticals or carriers to arterial lumens following angioplasty or endarterectomy, or chemotherapeutic agents to tumor vasculature might be practicable. 4 Thus, it is an effective method to directly immobilize various biocompatible substances, such as poly(ethylene glycol) (PEG), zwitterionic materials, heparin, and hyaluronic acid (HA), onto the surface of a metallic biomaterial in order to obtain a good biocompatibility.…”

Section: Introductionmentioning

confidence: 99%

“…Dopamine (3,4-dihydroxyphenylethylamine (DA)) is a highly reactive molecule that oxidizes at alkaline pH values to convert the adherent catechol/quinone forms, which can be used for facile modification of various surfaces such as polymers, metals, and ceramics. 9 In the adhesion of dopamine to substrates, various interactions were involved by the surface chemistry including covalent bond with amino and thiol groups, coordination bond, and hydrogen bonding.…”

Section: Introductionmentioning

confidence: 99%

Optimal conjugation of catechol group onto hyaluronic acid in coronary stent substrate coating for the prevention of restenosis

et al. 2016

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Although endovascular stenting has been used as an interventional therapy to treat cardio- and cerebro-vascular diseases, it is associated with recurrent vascular diseases following stent thrombosis and in-stent restenosis. In this study, a metallic stent was coated with dopamine-conjugated hyaluronic acid with different ratios of catechol group to improve hemocompatibility and re-endothelialization. Especially, we were interested in how much amount of catechol group is appropriate for the above-mentioned purposes. Therefore, a series of dopamine-conjugated hyaluronic acid conjugates with different ratios of catechol group were synthesized via a carbodiimide coupling reaction. Dopamine-conjugated hyaluronic acid conjugates were characterized with 1H-nuclear magnetic resonance and Fourier transform infrared spectroscopy, and the amount of catechol group in dopamine-conjugated hyaluronic acid was measured by ultraviolet spectrometer. Co-Cr substrates were polished and coated with various dopamine-conjugated hyaluronic acid conjugates under pH 8.5. Dopamine-conjugated hyaluronic acid amounts on the substrate were quantified by micro-bicinchoninic acid assay. Surface characteristics of dopamine-conjugated hyaluronic-acid-coated Co-Cr were evaluated by water contact angle, scanning electron microscopy, and atomic force microscopy. The hemocompatibility of the surface-modified substrates was assessed by protein adsorption and platelet adhesion tests. Adhesion and activation of platelets were confirmed with scanning electron microscopy and lactate dehydrogenase assay. Human umbilical vein endothelial cells were cultured on the substrates, and the viability, adhesion, and proliferation were investigated through cell counting kit-8 assay and fluorescent images. Obtained results demonstrated that optimal amounts of catechol group (100 µmol) in the dopamine-conjugated hyaluronic acid existed in terms of various properties such as hemocompatibility and cellular responses.

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Corrosion of and changes in biological effects of cobalt chrome alloy and 316L stainless steel prosthetic particles with age

Haynes

Crotti

Haywood

2000

J. Biomed. Mater. Res.

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The biological response to prosthetic wear particles is thought to stimulate the bone loss that often leads to prosthetic joint failure. This in vitro study investigates how metal particles corrode under physiological conditions and how biological responses to particles may change as particles age. Cobalt chrome alloy (CoCr) and 316L stainless steel (SS) particles of a similar size, shape, and concentration to those found in revision tissues were used. The release of soluble metal (Co and Cr from CoCr particles and Fe from 316L SS) was markedly reduced with time under physiological conditions. CoCr particles released far more Co than Cr. The biological responses to aged and freshly produced particles were tested using human monocytes because wear particles are usually associated with this type of cell in the periarticular tissues. Aged particles of both metals were markedly less toxic to monocytes than freshly produced particles. Aged particles also appeared to stimulate the release of more IL-6 and prostaglandin E(2) from monocytes. The results show that CoCr and 316L SS particles become less toxic but may induce more bone resorbing mediators as they age in vivo.

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Cobalt in periprosthetic soft tissue: Observations in 6 revision cases

Cited by 18 publications

References 30 publications

Elevated Serum Cobalt With Metal-on-Metal Articulating Surfaces

Elevated Serum Cobalt With Metal-on-Metal Articulating Surfaces

Optimal conjugation of catechol group onto hyaluronic acid in coronary stent substrate coating for the prevention of restenosis

Corrosion of and changes in biological effects of cobalt chrome alloy and 316L stainless steel prosthetic particles with age

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