The effect of zinc sulphate and placebo was compared in a double-blind trial in 56 patients suffering from acne vulgaris. Serum vitamin A levels were studied in all, before and at the end of therapy, 29 patients received zinc sulphate 600 mg daily and 27 patients received placebo. Patients on placebo showed no improvement. After 12 weeks of treatment with zinc sulphate, 17 patients (58%) showed significant improvement. There was a statistically significant decrease in the number of papules, infiltrates and cysts. In zinc-treated cases there was statistically significant increase in serum vitamin A levels, while no change was found in the placebo group.
Introduction: Esophageal varices are generally the most common clinical manifestation of portal hypertension in Patients of liver cirrhosis. Most common causes of death in liver cirrhosis are hemorrhage from esophageal varices. The present study has been carried out to identify clinical, biochemical and ultrasonographic parameters which might non-invasively predict the existence and the risk of variceal bleed. Material and Methods: The present prospective observational study was conducted in 2 years among 100 patients suffering from liver cirrhosis above 18 years of age. Detailed history, clinical examination, investigations to fulfill the inclusion and exclusion criteria of all patients was taken. Different non endoscopic parameters were taken Plateletcount, Coagulation profile, Ultrasonography whole abdomen, Child-Pugh-Torcotte (CPT) Score, AST to platelet ratio index (APRI) for the detection of esophageal varices and its grading in liver cirrhosis patients which was confirmed by endoscopy. Results: There was significant association of presence of esophageal varices in liver cirrhosis patients with presence of icterus, presence of ascites,presence of splenomegaly, grade of Child Pugh Score, AST to Platelet rationdex (APRI score) Prothrombin Time and International Normalized Ratio(PT/ INR), mean TB (mg/dl), mean spleen size. Conclusions: The result of present study concluded that some parameters are strongly associated with grades of varices and could be useful for early detection and subsequent management of varices.
Introduction: Dengue fever is a systemic acute viral illness caused by Arbo virus from genus flavivirus highly prevalent in the tropics and subtropics, transmitted by Aedes (aegypti and albopictus) mosquito. Pathogenesis of AKI due to dengue include direct action by the virus, hemodynamic instability, rhabdomyolysis, hemolysis and acute glomerular injury.This study was planned to know the incidence and severity of AKI in patients of Dengue fever. Material and methods: Our study was an observational retrospective study, done in Subharti Medical College, Deptt. Of Medicine, Meerut between july 2017-December 2018. Medical records of 320 Dengue IgM+ patients admitted during this period were studied. Patients were classified into dengue fever, dengue hemmorhagic fever, dengue shock syndrome. Results: Out of total 320 patients positive for dengue IgM, 48 patients (15%) were found to develop AKI. Out of the total 48 patients developing AKI, 26 patients presented with Dengue fever, 16 were with Dengue Hemmorhagic Fever and 6 presented with dengue shock syndrome. Out of the 48 patients diagnosed with AKI, 34 patients fall under KDIGO criteria I, 10 patients fall under KDIGO II, 4 patients fall under KDIGO III. Conclusion: Our study concluded that AKI is a major and serious complication,and it is the major cause of Mortality and morbidity in dengue fever.
BACKGROUND Alcohol consumption is prevalent all over world since ages. In men 40-80 g/d of ethanol produces fatty liver; 160 g/day for 10-20 years causes hepatitis or cirrhosis. Only 15 percent of alcoholics develops alcoholic liver disease. Cirrhosis is the final result of hepatic fibrosis and is reversible in the middle stages of development between fibrogenesis and fibrolysis. This disease leads to hemodynamic disorders that can have widespread impacts in the body according to the severity of the cirrhosis. Autonomic dysfunctions have been observed in patients with chronic liver disease. In most of these cases, autonomic dysfunction has been attributed to an alcohol-mediated neuropathy, but other liver-related mechanisms are conceivable as chronic alcoholics with liver damage have higher frequency of neuropathy than those without it. METHODS The study group consisted of 100 patients, aged 25-60 years of age diagnosed with alcoholic liver cirrhosis on the basis of clinical history and laboratory investigations. RESULTS The distribution of age in study population was found to be 41% and 59% in the age group 25-40 and 40-60 years respectively. Among 100 patients recruited for the present study, 71 patients were found to have autonomic dysfunction. The prevalence of autonomic dysfunction was found to be 71% of study population with alcoholic liver cirrhosis. QTc interval was found to be prolonged in cirrhotic patients with autonomic dysfunction as compared to no autonomic dysfunction patients. The abnormality in orthostatic hypotension, HR response to standing and ECG resting tachycardia were found to be statistically significantly associated with Child Pugh Score. CONCLUSIONS Autonomic dysfunction becomes more prominent with the severity of alcoholic liver cirrhosis. Autonomic dysfunction increases the morbidity and mortality among patients with alcoholic liver cirrhosis.
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