Oral zinc sulphate therapy in acne vulgaris: a double-blind trial

Verma, Kalpana; Saini, A S; Dhamija, Shantanu

doi:10.2340/0001555560337340

Cited by 50 publications

(8 citation statements)

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“…Of these, 2489 records were excluded based on title and abstract screening. Among 93 full-text articles assessed for eligibility, 42 articles (3346 participants) [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] met the inclusion criteria and were included in the review (Figure). Of the included studies, 27 (64.3%) 6, 7, 9, 12, 13, 17, 19-21, 23, 24, 27, 29, 30, 32, 36-40, 42-47 were of poor quality, 11 (26.2%) 8,10,11,[14][15][16]18,22,28,31,34,35 were of fair quality, and 4 (9.5%) 25,26,33,41 were of good quality (Table 1, Table 2, and Table 3).…”

Section: Resultsmentioning

confidence: 99%

“…Of these, 2489 records were excluded based on title and abstract screening. Among 93 full-text articles assessed for eligibility, 42 articles (3346 participants) met the inclusion criteria and were included in the review (Figure). Of the included studies, 27 (64.3%) were of poor quality, 11 (26.2%) were of fair quality, and 4 (9.5%) were of good quality (Table 1, Table 2, and Table 3).…”

Section: Resultsmentioning

confidence: 99%

“…Among 93 full-text articles assessed for eligibility, 42 articles (3346 participants) met the inclusion criteria and were included in the review (Figure). Of the included studies, 27 (64.3%) were of poor quality, 11 (26.2%) were of fair quality, and 4 (9.5%) were of good quality (Table 1, Table 2, and Table 3). Detailed information on the included studies, including for poor-quality studies, is available in the eTable in the Supplement.…”

Section: Resultsmentioning

confidence: 99%

“…Zinc is thought to target acne through decreasing sebum production and anti-inflammatory mediators as well as through antibacterial effects on Cutibacterium acnes, though its exact mechanisms are not fully understood. 48 Of the 15 articles evaluating zinc in the treatment of acne, [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] 4 of 6 studies (66.7%) of fair quality 10,11,14,16 and 4 of 9 studies (44.4%) of poor quality 6,9,13,17 found zinc to be efficacious (Tables 1-3 and eTable in the Supplement).…”

Section: Zincmentioning

confidence: 99%

“…There was no significant difference in the rates of subjective improvement (37% vs 19% with improvement; P > .05). Improvement of acne with zinc sulfate (600 mg/d) compared with placebo was demonstrated in another double-blind trial of 56 patients by Verma et al 11 Of the 29 patients receiving zinc sulfate, 14 showed some improvement (3 excellent, 10 moderate, and 1 slight) after 6 weeks of treatment, while patients in the placebo group either showed no improvement or aggravation of their acne. In the zinc-treated group, there was also a statistically significant decrease in the number of papules (mean [SD], 29.38 [12.50] to 7.41 [4.61]), infiltrates (mean [SD], 1.65 [2.89] to 0.29 [1.17]), and cysts (mean [SD].…”

Section: Zinc Sulfatementioning

confidence: 99%

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Safety and Effectiveness of Oral Nutraceuticals for Treating Acne

Shields,

Ly,

Wafae

et al. 2023

JAMA Dermatol

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ImportancePatients with acne are interested in nutraceuticals as a potential treatment option. However, there is uncertainty regarding the efficacy and safety of these products.ObjectiveTo evaluate the evidence for oral nutraceuticals in the treatment of acne.Evidence ReviewThe PubMed, Embase, Cochrane Central Register of Controlled Trials, and Web of Science databases were searched from inception through January 30, 2023, to identify randomized clinical trials evaluating oral nutraceutical interventions (ie, vitamins and minerals, botanical extracts, prebiotics, and probiotics) in individuals with acne. Clinician-reported outcomes (eg, investigator global assessment, lesion counts), patient-reported outcomes (eg, quality of life), and adverse events were extracted from the included studies. The quality of evidence was assessed using the Cochrane Risk of Bias checklist tool for randomized clinical trials. Based on the Risk of Bias tool, articles were converted to Agency for Healthcare Research and Quality standards of good, fair, or poor quality.FindingsA total of 2582 abstracts were identified in the database search, 42 of which met inclusion criteria (a total of 3346 participants). Studies of fair or good quality showed the potential benefit of vitamins B5 and D, botanical extracts (green tea), probiotics, and ω-3 fatty acids in the treatment of acne. These interventions were most frequently associated with decreased lesion counts or improved investigator global assessment scores. Adverse effects were rare for most of the therapies evaluated, but gastrointestinal tract adverse effects were reported for zinc therapy.Conclusions and RelevanceThis systematic review suggests a possible role for nutraceutical supplements in the treatment of acne. Physicians should be prepared to discuss the evidence regarding the potential role of nutraceuticals with patients. Many studies were of small size, and future research should focus on larger randomized clinical trials to assess the utility of nutraceuticals in the treatment of acne.

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