A Study on Actue Kidney Injury in Patients of Dengue Fever in Western Uttar Pradesh Population

Abstract

Introduction: Dengue fever is a systemic acute viral illness caused by Arbo virus from genus flavivirus highly prevalent in the tropics and subtropics, transmitted by Aedes (aegypti and albopictus) mosquito. Pathogenesis of AKI due to dengue include direct action by the virus, hemodynamic instability, rhabdomyolysis, hemolysis and acute glomerular injury.This study was planned to know the incidence and severity of AKI in patients of Dengue fever. Material and methods: Our study was an observational retrospective study, done in Subharti Medical College, Deptt. Of Medicine, Meerut between july 2017-December 2018. Medical records of 320 Dengue IgM+ patients admitted during this period were studied. Patients were classified into dengue fever, dengue hemmorhagic fever, dengue shock syndrome. Results: Out of total 320 patients positive for dengue IgM, 48 patients (15%) were found to develop AKI. Out of the total 48 patients developing AKI, 26 patients presented with Dengue fever, 16 were with Dengue Hemmorhagic Fever and 6 presented with dengue shock syndrome. Out of the 48 patients diagnosed with AKI, 34 patients fall under KDIGO criteria I, 10 patients fall under KDIGO II, 4 patients fall under KDIGO III. Conclusion: Our study concluded that AKI is a major and serious complication,and it is the major cause of Mortality and morbidity in dengue fever.