This paper describes the clinical and pathological features of leishmaniasis in three dogs imported into the U.K. Principal signs were wasting, lymphomegaly, keratoconjunctivitis, and extensive skin lesions that included exfoliative dermatitis and alopecia. Autopsy showed widespread chronic inflammatory lesions throughout lymphoid and other tissues associated with parasitized macrophages. The paper discusses the potential human health hazard posed by a zoonosis characterized by non‐specific signs and prolonged periods of quiescence. Euthanasia is recommended for cases positively diagnosed as leishmaniasis.
One hundred dogs bearing malignancies of the oropharyngeal region were examined over a three‐year period and prospectively staged using the World Health Organisation TNM Classification of Tumours of Domestic Animals. Primary tumours were characterized by their large size or local infiltration (71 per cent, T3 status) and invasion into adjacent bone (60 per cent, Tb status). Regional lymph node metastasis was less common (17 per cent, N1b, N2b or N3 status) and distant metastasis was an unusual presenting feature (5 per cent, M1 status). The early Stage I and II tumours together accounted for 8 per cent of the total series whilst the more advanced Stage III group were by far the most frequent, representing 84 per cent. The remaining 8 per cent being classified as Stage IV because of extensive regional or distance metastatic deposits. Prognoses by stage showed actuarial survival rates at 12 months of 100 per cent for Stage I, 71 per cent for Stage II, 31 per cent for Stage III with no survivors in the Stage IV group. Survival rates for the major histological types were 44 per cent for the non‐tonsillar squamous cell carcinoma, 22 per cent for the tonsillar squamous cell carcinoma and fibrosarcomas, 17 per cent for mastocytomas whilst none of the malignant melanomata survived 12 months.
This paper presents clinical, radiographic and pathological appearances in a case of pulmonary alveolar lipoproteinosis in a one‐year‐old Cocker Spaniel. This condition, well recognized in man appears not to have been reported previously as a spontaneous disease in the dog.
The main features were insidious decreased exercise tolerance and increasing respiratory embarrassment. Radiographic lung changes were associated with filling of pulmonary alveoli with PAS‐positive lipoproteina‐ceous material. Inflammatory changes were minimal. The alveolar material consisted of excessive amounts of a substance that resembled surfactant.
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