The relative risk of developing colorectal cancer after cholecystectomy was assessed retrospectively in 493 patients with colorectal cancer (239 women, 254 men). The results were compared with a control group of patients matched for sex and age. The overall relative risk was 0.7 (90% confidence interval, 0.7-0.8). However, when the data were analysed for site significant differences were seen. In the caecum and ascending colon the relative risk of developing colorectal cancer after cholecystectomy was 2.8 (90% confidence interval, 1.0-9.4). In the rectum the relative risk was only 0.3 (90% confidence interval, 0.2-0.6) in both sexes. The results suggest a relative increased risk of developing right-sided colon cancer after cholecystectomy in women. However, they only partially support the hypothesis that prior cholecystectomy increases the relative risk of developing colorectal cancer in view of the data relating to the rectum.
In recently transplanted patients, in patients studied for 18 months post transplant and in stable patients receiving CyA, the increase of SBA levels might be related to CyA treatment. This effect might be attributed to its cholestatic effect and also to a modification in uptake, metabolism, synthesis and excretion of SBA in the hepatocyte. These conclusions are supported by the results obtained in stable transplanted patients without CyA treatment showing normal SBA levels.
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