Relative risk of colorectal cancer after cholecystectomy

Mamianetti, A; Cinto, R O; Altolaguirre, D; Bosicio, O A; Heidenreich, A; Salomón, Mario

doi:10.1007/bf01660717

Cited by 16 publications

(7 citation statements)

References 26 publications

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“…Our search was done totally independently of this study before results were compared. In addition we found an extra 6 which were mis-E. Kyriacou, R. Knill-.lones coloproctolgy 19 (1997 [4,5,9,17,23,25,35,37,40,43,51,53,61,73,75] (not in the order shown graphically).…”

Section: Discussionmentioning

confidence: 86%

“…There are expected differences in the age groups looked at, for example Rundgren and Mellstrom [68] looked at patients aged 70 to 75 years. Some trials have studied patients in 2 or more centres [51], or have mixed population and hospital data -despite trying to match areas of socio-economic equivalence. Radiology, laparotomy, histology, of autopsy, have been used to establish cases of colorectal cancer from the point of view of design of the various studies.…”

Section: Discussionmentioning

confidence: 98%

“…Very few studies have looked at the effects of diet, of smoking. Some studies have found an increased risk in proximal colon cancer associated with cholecystectomy [4,12,45,68,72,79,80,82], and in many cases where the risk of right sided colonic cancer has been looked at the association is strongest in women [15,22,51,58,59,62,65,73,75]. Other studies have found an overall increased susceptibility to colorectal carcinoma at any site in both men and women [5,43,44,52,55], or mainly in the rectum [13].…”

Section: Discussionmentioning

confidence: 98%

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The role of previous cholecystectomy in patients with colorectal cancer

Kyriacou

Knill‐Jones²

1997

Coloproctol

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Summary. There is a large body of literature which undertakes to look at a possible association between cholecystectomy and colorectal cancer. We set out to conduct a meta-analysis to investigate this. The overall odds ratio for all studies looked at was 1.36 with 95% confidence intervals (CI) 1.07 to 1.74, significant at the 5% level (p = 0.014). The overall odds ratio fora subset of studies deemed "good studies" established by a customised ranking score was 1.66 (1.34 to 2.03), p < 0.0001. The odds ratios for cohort and necropsy studies were also ascertained and discussed. Our results would tend to support the above hypothesis. However, the limitations of this review are also discussed, and finally we suggest that if such ah association is indeed real then the increased risk is likely to be small.

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Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 98%

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The role of previous cholecystectomy in patients with colorectal cancer

Kyriacou

Knill‐Jones²

1997

Coloproctol

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“…While the relationship between cholecystectomy and cancer, most notably colorectal cancer (24,28–41) , has been evaluated in a number of studies, the literature specifically evaluating the association between gallbladder disease and endometrial cancer is sparse. The endometrium is a sensitive target tissue for estrogenic stimulation, with strong relative risks associated with unopposed estrogen use (42,43) , obesity (15,44) , and smoking (an exposure that reduces serum estrogen levels) (45–48) .…”

Section: Discussionmentioning

confidence: 99%

Cholecystectomy and endometrial cancer: a marker of long-term elevated estrogen exposure?

Morimoto¹,

Newcomb²,

Hampton³

et al. 2006

Int J Gynecol Cancer

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Excess hormones, both endogenous and exogenous, are implicated in the etiology of endometrial cancer. We considered whether having had gallstones or a cholecystectomy (surgery to remove the gallbladder), which are more common in women who are obese and who use exogenous hormones, might be a marker for high lifetime levels of estrogen. We conducted a population-based study of endometrial cancer cases and community controls in women aged 40-79 years. Participants completed an interviewer-administered questionnaire that elicited exposures prior to diagnosis or reference date, including history of gallstones and cholecystectomy, as well as reproductive history, lifetime body mass, smoking, postmenopausal hormone (PMH) use, and other risk factors. Compared to controls, cholecystectomy was associated with a 50% increased risk of developing endometrial cancer (odds ratio = 1.5 [1.1-2.0]). The relationship appeared to depend upon PMH user status; the association was observed only among never hormone users. Body mass index did not appear to modify this relationship. Having a diagnosis of gallstones was also associated with endometrial cancer, although to a lesser magnitude. Although other etiologic factors may play a role in the relation between cholecystectomy and endometrial cancer, the current analysis suggests that this association is attributable, at least in part, to the sharing of hormonal risk factors.

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“…All cholecystectomies were performed at least 1 year before rectal cancer diagnosis Moorehead 1989 All cholecystectomies were performed at least 10 years before rectal cancer diagnosis Caprilli 1989 All cholecystectomies were performed at least 2 years before rectal cancer diagnosis Li Destri 1989 Time from cholecystectomy to diagnosis of rectal cancer ranged from 4 to 33 years with an average of 17 years Kune 1988 Time from cholecystectomy to diagnosis of rectal cancer averaged 13.5 years Mamianetti 1988 Time from cholecystectomy to diagnosis of rectal cancer ranged from 1 to 41 years with an average of 15.7 years Friedman 1987…”

Section: Publication Biasmentioning

confidence: 99%