Gallstone disease is associated with rectal cancer: a meta-analysis

Chiong, Corinna; Cox, Michael R.; Eslick, Guy D.

doi:10.3109/00365521.2012.660538

Cited by 23 publications

(13 citation statements)

References 77 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…3,8,36 The status post cholecystectomy was also related to hepatic cancer, colorectal cancer, and gastric cancer. 2,3,21,37,38 However, there are few studies that focused on cancer risks in cholecystitis.…”

Section: Specific Cancer Typesmentioning

confidence: 98%

Risk of Cancer in Patients with Cholecystitis: A Nationwide Population-based Study

Lee

et al. 2015

The American Journal of Medicine

View full text Add to dashboard Cite

Section: Specific Cancer Typesmentioning

confidence: 98%

Risk of Cancer in Patients with Cholecystitis: A Nationwide Population-based Study

Lee

et al. 2015

The American Journal of Medicine

View full text Add to dashboard Cite

“…A meta-analysis of 42 studies encompassing 14226 incident cases showed no significant risk of rectal cancer following cholecystectomy (OR = 1.14, 95%CI: 0.92-1.41) [70] . This finding is supported by three other case-control studies [53,62,63,65] and two cohort studies [56,64] .…”

Section: Rectal Cancermentioning

confidence: 99%

“…Six studies (4 case-control; 2 cohort) demonstrated a positive association between proximal colon cancer and cholecystectomy [59,62,63,[67][68][69][70][71][72][73][74][75][76][77][78][79] . An extremely high association (OR = 5.85, 95%CI: 2.13-16.7) was found in one particular Chinese study but 95%CIs were broad and a low quality assessment score indicates these findings are somewhat unreliable [62] .…”

Section: Proximal Colon Cancermentioning

confidence: 99%

Cholecystectomy and the risk of alimentary tract cancers: A systematic review

Coats

Shimi

2015

WJG

View full text Add to dashboard Cite

show abstract

“…Goldach et al conclude that cholecystectomy does not cause cancer [15]. Chiong suggests that cholelithiasis increases the risk of rectal cancer, and cholecystectomy does not infl uence this pathology [16]. Schmidt et al obtained inconclusive results to draw a fi rm conclusion [17].…”

Section: Discussionmentioning

confidence: 99%

The Association of Cholelithiasis and Colorectal Cancer

C¹,

Molnar²,

Panțiru³

et al. 2014

Acta Medica Marisiensis

View full text Add to dashboard Cite

Background: In the literature there are a number of studies that suggest a possible correlation between cholelithiasis/cholecystectomy and colorectal cancer. The exposure of the colon mucosa to the action of bile acids that potentially have a carcinogenic effect due to the change in anatomy after cholecystectomy, seems to be the explanation of this association. The purpose of this paper was to search for such a correlation in our study group. Methods: We performed a retrospective cross-sectional study, analyzing the patients admitted to the First Surgical Clinic of the County Emergency Clinical Hospital Tîrgu Mureș, between January 1 st , 2005 -December 31 st , 2010. Analyzing the medical records, operation protocols and histopathological results, we paid attention to demographics, location of neoplasia, the time elapsed since the cholecystectomy to the discovery of neoplasia, histological types, trying to perform correlations between these parameters and the lithiasic factor. Results: Out of the 534 patients admitted and operated with the diagnosis of colorectal cancer, 15.6% (n = 83) showed a history of gallbladder stone affection. Most patients came from urban areas, the average age was 67.2 (range 39-88 years), females were more affected. The most common locations were: the sigmoid colon (26.5%), rectum (36.3%) and the most common histological form was moderately differentiated adenocarcinoma. Conclusions: Similar to other studies, our work suggests a slight increase in the incidence of colorectal cancer in patients that underwent a cholecystectomy, without drawing a fi rm conclusion. We deem it necessary to see if diet changes of the Romanian population affect this relationship.

show abstract

Gallstone disease is associated with rectal cancer: a meta-analysis

Abstract: Cholelithiasis increases the risk of rectal cancer. No association exists between cholecystectomy and rectal cancer.

Cited by 23 publications

References 77 publications

Risk of Cancer in Patients with Cholecystitis: A Nationwide Population-based Study

Risk of Cancer in Patients with Cholecystitis: A Nationwide Population-based Study

Cholecystectomy and the risk of alimentary tract cancers: A systematic review

The Association of Cholelithiasis and Colorectal Cancer

Contact Info

Product

Resources

About