is a chronic autoimmune disease characterized by changes in the growth and differentiation of the epidermis. 2-5 % of the population of the planet have psoriasis, and it is 30 % in the structure of skin diseases. The multifactorial concept of the pathological process in psoriasis determines a wide range of pharmacotherapy of this disease. Modern antipsoriatic agents are not effective enough and have a variety of side effects.Aim. To summarize the existing scientific literature data conserning the possibility of treating psoriasis with carboxytherapy.Results and discussion. Carboxytherapy is an important part of the treatment and rehabilitation of patients with psoriasis. The antipsoriatic effect of carboxytherapy is realized through the local and resorptive effect of CO 2 : antiproliferative, antiinflammatory, antioxidant, antimicrobial, antihypertrophic, reparative and analgesic. Carboxytherapy in psoriasis promotes tissue detoxification, improves immunity, improves tissue trophism, and eliminates venous-interstitial lymphatic stagnation due to hemodynamic, tissue, and biochemical mechanisms of action of СО 2 .Conclusions. Carboxytherapy as an additional alternative to pharmacotherapy has a synergistic effect together with formulary therapy, but at the same time reduces the dosage of approved drugs and their side effects.
The potential of carboxytherapy in diseases of the urogenital system organs Recently carboxytherapy has been widely used for the treatment of many diseases, and it is associated with the high efficiency and low cost. Carboxytherapy as the method of treatment has been used for 70 years in the international medical practice and more than 50 years in aesthetic medicine. Aim. To substantiate the use of carboxytherapy as an innovative method of treatment for diseases of the urogenital system organs. Materials and methods. The analysis of scientific sources concerning the treatment of sexual dysfunction, erosion of the cervix, menopause, vulvovaginal atrophy, initial stages of the stress urinary incontinence, erectile dysfunction, and impotence was performed. Results. It has been determined that various variants of carboxytherapy can be used to obtain the antihypoxic, reparative-regenerative, spasmolitic, anti-inflammatory, analgesic and antioxidant effects in clinical practice as a result of the treatment. Patients with different pathologies of the urogenital system noted improvement in functioning of urogenital organs, release of pain, decrease in inflammation, mood stability, and good mental and physical performance. Therefore, the quality of life has been improved. Conclusions. Thus, СО 2 can be considered as a unique medicinal product, and carboxytherapy as an alternative treatment for many diseases.
The aim of the study was to analyze the mechanisms of action and pharmacodynamics of carboxytherapy in diseases of the cardiovascular system (CVS). Materials and methods. An analysis of domestic and foreign experience in the use of carboxytherapy for diseases of CVS. Results and discussions. The mechanism of action of carboxytherapy is based on the principle of the introduction of carbon dioxide (CO2) in the patient's body, due to which many pathological disorders can be eliminated. Inhalation and non-inhalation introduction of CO2 into the body has been used for medicinal purposes for many decades. The empirical (off label) use of this therapy in course of time has gained a wide clinical evidence base. There is a large amount of clinical evidence in the world of the effective use of carboxytherapy in many fields of medicine, including those with CVS diseases. It is proved that CO2 introduced into the body penetrates freely through cell membranes and has antihypoxic, vasodilating, antioxidant, anti-ischemic, antispasmodic and other positive effects. Therefore, carboxytherapy contributes to a complex of pharmacological effects inherent of traditional antianginal, hypotensive, antispasmodic and other drugs that are widely used in the treatment of CVS diseases. Conclusions. An analysis of domestic and foreign experience in carboxytherapy shows that the effects of CO2 in diseases of the CVS are achieved by improving oxygenation and microcirculation, anti-anginal, anti-inflammatory, antihypertensive, antispasmodic, anti-oxidant, and analgesic effects of this gas. Carboxytherapy is an alternative, promising and safe method of treating diseases of the cardiovascular system.
The carbon dioxide of the body is the most important natural regulator of respiration, blood circulation, metabolism, electrolyte balance, nervous system excitability, smooth muscle tonus. Carboxytherapy is based on the use of carbon dioxide. It is an effective and safe method of many diseases’ treatment due to its rich pharmacodynamics. Inhalation of CO2 is used in resuscitation and anesthesiology practice. Another area of CO2 application in surgery is intra‑abdominal insufflation for all endoscopic laparoscopic procedures. Carbon dioxide is quickly absorbed by the mucous membrane of the gastrointestinal tract, which causes an increased interest in its use as an insufflation agent for all endoscopic procedures. In addition, CO2 has antispasmodic, analgesic, anti‑inflammatory and antiseptic effects, which is important for these diagnostic measures. CO2 insufflation during a colonoscopy causes less post‑procedure pain and distension of the intestine without significant changes in pCO2 compared to air one. An additional mechanism for pain reducing after the CO2 procedure may be the vasodilating effect of CO2 and its spasmolytic action on the wall in the enlarged part of the colon. For the past 50 years, CO2 has been used in cardiothoracic surgery to remove air from the surgical area, which reduces the air embolism probabily during heart surgery. Recently, heated and hydrated CO2 insufflation is used as a method to reduce the infections rate at the surgery site in an open wound. A carbon dioxide laser has physical, biological and surgical properties valuable for the surgeon. Carbon dioxide is also used as an alternative diagnostic contrast agent. Therefore, CO2 due to its antibacterial, antihypoxic, antispasmodic, analgesic, anti‑inflammatory, antioxidant properties and the side effects absence is an important component of therapeutic and diagnostic procedures in surgery, anesthesiology, gynecology, dermatology and other fields of medicine.
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