Examination of thymus glands from Beagles used in routine toxicological experiments revealed an age‐related increase in the incidence and size of cysts of branchial origin in the groups: 28–30 months, 16–18 months, 10–12 months, 6–8 months.
The cysts varied in size and in the distribution of the cell types constituting the epithelium. Histochemical examination of cyst contents revealed mucosubstances that were considered similar to those of normal respiratory mucins in man.
SUMMARY
The incidence of small cysts of branchial arch origin in the thymus of beagles was seen to increase with age. The increase is considered to be greater than that attributable to the regression of surrounding thymic tissue alone. Reference is made to a clinical case in which cystic distension of the thymus was present.
Résumé. L'examen de thymus de chiens Beagle utilisés en expériences courantes de toxicologie a fait ressortir un accroissement proportionnel à l'âge dans la fréquence et la dimension des kystes d'origine branchiale, dans les groups de 28–30 mois, 16–18 mois, 10–12 mois, 6–8 mois.
Les kystes présentaient des variations de grosseur, ainsi que dans la répartition des cellules type constituant l'épithélium. L'analyse histochimique du contenu des kystes a révélé des mucosubstances considtétés similaires à celles des mucosités normales du système respiratoire de l'homme.
Zusammenfassung. Prüfung der Thymusdrüsen von Hirschhunden in normalen toxikologischen Versuchen zeigte mit dem Alter zusammenhängende Steigerung im Auftreten und in der Größe von Zysten mit Kiemenurspxung in den Gruppen 28–30 Monate, 16–18 Monate, 10–12 Monate, und 6–8 Monate. In der Größe der Zysten und in der Verteilung der das Epithelgewebe bildenden Zellentypen waren Schwankungen festzustellen. Histochemische Untersuchung der Zysteninhalte ergab Schleimsubstanzen, die ähnlich den normalen Mucinen in den Atmungswegen des Menschen erschienen.
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