Some observations on spontaneously occurring tumours of the central nervous system of sprague‐dawley derived rats

Mawdesley-Thomas, Lionel E.; Newman, A.J.

doi:10.1002/path.1711120206

Cited by 27 publications

(4 citation statements)

References 14 publications

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“…Tumor cells proliferated in the dilated ventri- No metastatic lesion were detected in the other than the brain. The findings in the present case are very similar to those of ependymoma described by previous workers [3][4][5][6].…”

supporting

confidence: 92%

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Ependymoma in a Rat

Yamasaki

Fukushima

1986

Experimental Animals

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supporting

confidence: 92%

“…One of them is glioma often detected in the cerebral hemispheres, most of which are astrocytoma, and ependymoma is less frequent [3][4][5].…”

mentioning

confidence: 99%

Ependymoma in a Rat

Yamasaki

Fukushima

1986

Experimental Animals

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“…On the other hand, that of malignant reticulosis has been used from the proposal of Garman in Monographs on Pathology of Laboratory Animals sponsored by the International Life Sciences Institute in 1988. Similar tumors have previously been reported as neoplastic reticulosis, reticulo-sarcoma, polymorphic cell sarcoma, and so on (Gopinath 1986; Krinke et al 1985; Mawdesley-Thomas and Newman 1974; Newman and Mawdesley-Thomas 1974).…”

Section: Introductionsupporting

confidence: 84%

Histological and Immunohistochemical Studies on Spontaneous Rat Astrocytomas and Malignant Reticulosis

Nagatani

Andõ²,

Yamakawa

et al. 2009

Toxicol Pathol

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Among spontaneous neoplasms of the rat central nervous system, the discrimination between astrocytoma and malignant reticulosis (MR) is sometimes difficult because of their similar cell morphology and infiltration patterns. In the present study, we carried out histological and immunohistochemical analyses on a total of sixty-four cases in Sprague-Dawley and F344 rats. These cases were diagnosed as benign/malignant astrocytoma containing no neoplastic oligodendroglial elements or MR according to the diagnostic criteria of the World Health Organization International Classification of Rodent Tumors (Mohr et al. 1994). Astrocytomas were divided into three types and MR into two types based on the number of lesions, cellularity and infiltration patterns, and so on. Although the neoplastic cells from all types showed various immunoreactivities for RM-4 (anti-rat macrophages and dendritic cells), ED-1, and/or vimentin, there were no distinctive differences among these types, and most cells that were positive for RM-4 were also positive for ED-1. None of the tumor types showed any reactivity for GFAP or S-100 protein. From the results of morphological and immunohistochemical examinations, it was indicated that there are no distinctive differences between spontaneous astrocytomas and MR in rats, and they are probably derived from the same cell lineage, that is, microglia, macrophage, or radial glia.

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“…Ivankovic et al (1966) did not observe any nervous-tissue tumours in more than 30,000 BD rats, a strain to which the BD-IV rats used in the present experiment pertain. Thomas and Schmahl (1964) did not observe any kidney tumours which could be considered as spontaneous in 5,000 BD rats and the general rarity of nervous-tissue and kidney tumours in different strains of rats has been reported (MacKenzie and Garner, 1973;Prejean et al, 1973;Fitzgerald et al, 1974;Boorman and Hollander, 1974;Mawdesley-Thomas and Newman, 1974;Newman and Mawdesley-Thomas, 1974).…”

Section: Discussionmentioning

confidence: 98%

The occurrence of tumours in f₁, f₂ and f₃ descendants of bd rats exposed to n‐nitrosomethylurea during pregnancy

Tomatis

Hilfrich

Turusov

1975

Intl Journal of Cancer

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N-nitrosomethylurea (NMU) was administered once IP at a dose of 20 mg/kg to BD female rats on the 18th day of pregnancy. The first generation descendants (F1) were mated to produce a second generation (F2), which were then mated to produce a third generation (F3). While F1 rats were exposed directly to NMU during intrauterine life, it can be reasonably excluded that F2 and F3 descendants were exposed to NMU or its metabolites. F2 and F3 rats received no other treatment and untreated rats served as controls. Kidney and nervous-tissue tumours were observed in F1 descendants and, with a lower incidence, in F2 descendants. In F3 rats, tumours of nervous tissue, but not of kidneys, were observed. These results confirm previous observations that exposure to a carcinogen during prenatal life results in an increased cancer risk which may persist for more than one generation.

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Some observations on spontaneously occurring tumours of the central nervous system of sprague‐dawley derived rats

Cited by 27 publications

References 14 publications

Ependymoma in a Rat

Ependymoma in a Rat

Histological and Immunohistochemical Studies on Spontaneous Rat Astrocytomas and Malignant Reticulosis

The occurrence of tumours in f₁, f₂ and f₃ descendants of bd rats exposed to n‐nitrosomethylurea during pregnancy

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Some observations on spontaneously occurring tumours of the central nervous system of sprague‐dawley derived rats

Cited by 27 publications

References 14 publications

Ependymoma in a Rat

Ependymoma in a Rat

Histological and Immunohistochemical Studies on Spontaneous Rat Astrocytomas and Malignant Reticulosis

The occurrence of tumours in f1, f2 and f3 descendants of bd rats exposed to n‐nitrosomethylurea during pregnancy

Contact Info

Product

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The occurrence of tumours in f₁, f₂ and f₃ descendants of bd rats exposed to n‐nitrosomethylurea during pregnancy